Opioid Dependency and Overdose – Cannabis Research

Opioid Dependency and Overdose Research Dashboard


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CannaKeys has 177 studies associated with Opioid Dependency and Overdose.

Here is a small sampling of Opioid Dependency and Overdose studies by title:

Components of the Opioid Dependency and Overdose Research Dashboard

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  • Chemotype guidance for treating Opioid Dependency and Overdose with cannabis
  • Synopsis of cannabis research for Opioid Dependency and Overdose
  • Individual study details for Opioid Dependency and Overdose

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Overview - Opioid Dependency and Overdose

Description of Opioid Dependency and Overdose

Opioids are produced synthetically or produced and sourced in the same fashion as heroin namely from the seed pods of the opium poppies. Opioids are prescription medication used to treat various pains and painful conditions such as after surgeries for example. And, while there are very useful and practical applications the abuse potential is significant. The abuse of and addiction to opioids is a significant global problem affecting the people from all walks of life demonstrating that pain and seeking relief is truly a shared human experience. To date the majority of opium poppies are grown in Afghanistan. Heroin is usually smoked or injected producing near instant analgesic euphoria. Dosing is critical. Too much can lead to sedation so severe that respiratory efforts seize and if not reversed produce rapid death. And, while the pharmaceutical versions of heroin, namely opioids, are commonly used in orthodox medicine heroin is illegal.

Disease Classification

Condition: Opioid Dependency
Disease Family: Addiction
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F11

Opioid Dependency and Overdose Symptoms:

Agitation, tachycardia, hypertension, abdominal cramps, pain, diaphoresis, craving for opioids, excessive yawning/sneezing, shaking of extremeties, diarrhea, insomnia

Also known as:

Opioid addiction, Opioid Overdose, Heroin addiction

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.