Various components of the endocannabinoid system (ECS) are expressed in the skin and play a significant role in maintaining skin homeostasis (balance) and, by extension, proper function. Furthermore, modulation of various components of the ECS has shown to produce therapeutic effects in reducing the itch in several different underlying pathologies such as inflammation, infection, auto-immune dysfunction, neuropathies, as well as several co-morbidities such as psoriasis, dermatitis, or cholestatic pruritus for example.
The CannaKeys pruritus treatment algorithm is based on review and analysis of scientific literature and clinical expert opinion. Focused on aspects that can be controlled in the clinical setting, it is designed to be used as a tool for creating optimal cannabinoid-based therapeutics for patients with pruritus while managing the complexities of the endocannabinoid system.
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Evidence-based Guidelines for Cannabis Therapeutics
We offer a systematic approach that physicians and healthcare professionals can use to make evidence-based decisions when prescribing cannabis or cannabinoids to treat pruritus. Factors that can make a significant difference in optimizing patient outcomes and producing effective anti-pruritic effects include the choice of a primary cannabinoid, specific dosing protocols, and form of administration.
Screening Process
Includes risk assessment, possible contraindications, and potential cannabinoid-to-pharmaceutical drug interactions.
Cannabinoid Treatment Plans
Dosing protocols consider patient preference regarding cognitive changes and altered states, and include starting dose, maximum daily dose, and titration rates for primary cannabinoid.
Cannabis-based Terpenes
Terpenes with therapeutic potential for the treating pruritus with links to clinical studies.
Nutraceuticals and Supplements
All relevant herbs and nutraceuticals that interact with the endocannabinoid system or the broader endocannabinoidome with clinical evidence for treating pruritus.
Microbiome and Dietary considerations
All dietary considerations and food products that engage the microbiome and interact with the endocannabinoid system or the broader endocannabinoidome with clinical evidence for treating or mitigating pruritus.
