Skeletal System Research Dashboard
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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 99 studies associated with Skeletal System.
Here is a small sampling of Skeletal System studies by title:
- A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain
- The Cannabinoids Effect on Bone Formation and Bone Healing
- The Therapeutic Potential and Usage Patterns of Cannabinoids in People with Spinal Cord Injuries: A Systematic Review
- The non-psychoactive phytocannabinoid cannabidiol (CBD) attenuates pro-inflammatory mediators, T cell infiltration, and thermal sensitivity following spinal cord injury in mice
- Efficacy and safety of cannabidiol followed by an open label add-on of tetrahydrocannabinol for the treatment of chronic pain in patients with rheumatoid arthritis or ankylosing spondylitis: protocol for a multicenter, randomized, placebo-controlled study
Components of the Skeletal System Research Dashboard
- Medical conditions associated with Skeletal System
- Synopsis of cannabis research for Skeletal System
- Chemotype guidance for Skeletal System
- Individual study details for Skeletal System
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Overview - Skeletal System
Description of Skeletal System
208 bones (counting three sternal sections) provide structure and support for the entire human body. Attachment to bones allows for muscular contraction and relaxation, the basis for physical movement. While the external portion of bones are made of dense connective tissues a mineral-based matrix (think honeycomb like) provides additional strengths and hollow spaces, for the storage of minerals, for the production of red and white blood cells as well as for blood vessels to provide movement of nutrients and perfusion.Skeletal System and ECS-Based Interactions
Cannabinoid receptors sites are abundantly present in bone and as such significantly modulate healthy skeletal structures. For instance, cannabinoids bind with CB1 and CB2 receptors to regulate osteoclast (cells that remove bone tissue) activity and bone mineral density alike—thus maintain bone density and prevent age-related bone loss.Skeletal System Medical Specialists
Orthopedist, Osteopath, Osteologist, ChiropractorAlso Known As:
N/ADrug Interactions
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
- THC low dose: 0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
- THC medium dose: 6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
- THC high dose: 21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
(sample conversion calculated on a person weighing 75kg)
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
- CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
- CBD high dose: 100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
- (upper limits tested ~1,500mg)
(sample conversion calculated on a person weighing 75kg)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.