Urinary System – Cannabis and Cannabinoid Research

Urinary System Research Dashboard

35

Primary Studies

17

Related Studies

52

Total Studies

Clinical Studies

2

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

15

Meta-analyses/Reviews

12

Animal studies

5

Laboratory studies

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CannaKeys has 52 studies associated with Urinary System.

Here is a small sampling of Urinary System studies by title:


Components of the Urinary System Research Dashboard

  • Medical conditions associated with Urinary System
  • Synopsis of cannabis research for Urinary System
  • Chemotype guidance for Urinary System
  • Individual study details for Urinary System

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Overview - Urinary System

Description of Urinary System

The urinary system starts anatomically with the kidneys which functions to eliminate waste (e.g. urea, ammonia, excess minerals) and to balance essential and needed compounds (e.g. metabolites, electrolytes, hormones) on a moment to moment basis. Excess materials or waste travels down the ureter into the bladder where it is collected until such time we choose to urinate when urine is voided through the urethra.

Urinary System and ECS-Based Interactions

Endocannabinoid cannabinoid receptor types (CB1, CB2) have been discovered in the kidneys and the lower urinary tract cells of mammals (i.e. monkeys and humans) and it is generally agreed upon that in healthy individuals the ECS plays a significant role in producing kidney homeostasis. To date, the specific mechanisms by which CB1 or CB2 receptors are involved in the pathology of acute kidney injuries (AKI) or chronic kidney disease (CKD) is subject to ongoing investigation and research has produced interesting results. For instance, while a number of case studies have shown that the usage of synthetic cannabinoids (those commonly found in potent street drugs such as ?spice? or ?K2?) have caused AKI in a number of users. Which stands in direct contrast to using plant-based cannabis with no known cases of AKI. In cases of CKD an observational study conducted on 1,225 kidney transplant recipients showed that cannabis use did not increased the risk of death or produced declining kidney function. And, ?-caryophyllene a CB2 activating terpene has shown to be powerful agent in preventing cisplatin-induced (chemotherapeutic agent) kidney toxicity.

Urinary System Medical Specialists

Urologist, Nephrologist

Also Known As:

Renal System

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.