Respiratory System – Cannabis and Cannabinoid Research

Respiratory System Research Dashboard

60

Primary Studies

37

Related Studies

97

Total Studies

Clinical Studies

10

Double-blind human trials

4

Clinical human trials

Pre-Clinical Studies

17

Meta-analyses/Reviews

11

Animal studies

18

Laboratory studies

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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 97 studies associated with Respiratory System.

Here is a small sampling of Respiratory System studies by title:


Components of the Respiratory System Research Dashboard

  • Medical conditions associated with Respiratory System
  • Synopsis of cannabis research for Respiratory System
  • Chemotype guidance for Respiratory System
  • Individual study details for Respiratory System

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Overview - Respiratory System

Description of Respiratory System

The respiratory system is made up of the organs of breathing (from top to bottom): the nose, mouth, pharynx, larynx, trachea, tracheal bifurcations (right and left), bronchi, bronchioles, and finally, the smallest but most abundant of the lungs architecture, the alveoli. Breathing begins with inhaling the air, continues with separating and attaching oxygen molecules (produced by the trees, plant, and plankton of the sea) to the hemoglobin, present in red blood cells, as they pass the alveoli. The respiratory cycle ends with exhaling the returning carbon-dioxide back into the atmosphere for the fauna and flora of land and sea to nourish and sustain themselves and thus completing a cycle of life of which we are an essential part.

Respiratory System and ECS-Based Interactions

To-date only a relative small number of studies have investigated the effect of cannabinoids on cells of the lungs. Endocannabinoid receptor sites (CB1, CB2) have been confirmed in cells of the upper airways (more CB1). In contrast, alveolar macrophages, immune cells have been found residing at the end of the respiratory tree the alveoli (more CB2) thus indicating a differential role for each (CB1 and CB2) depending on the position or affected part of the lungs (e.g. antitussive).

Respiratory System Medical Specialists

Pulmonologist, Respiratory Medicine, Pulmonary Medicine

Also Known As:

N/A

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.