Integumentary System – Cannabis and Cannabinoid Research

Integumentary System Research Dashboard


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CannaKeys has 559 studies associated with Integumentary System.

Here is a small sampling of Integumentary System studies by title:

Components of the Integumentary System Research Dashboard

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  • Synopsis of cannabis research for Integumentary System
  • Chemotype guidance for Integumentary System
  • Individual study details for Integumentary System

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Overview - Integumentary System

Description of Integumentary System

The integumentary system (aka the exocrine system) is comprised of skin, hair, nails. The skin covers the entire body in a single hole torus?like fashion (with the hole being the opening from the mouth to the anus) letting us know where the outside world ends and we begin. It is our first line of defense against harsh external contact, microbes, toxins, and ionizing radiation. It keeps water in and it keeps water out. It keeps us warm and it keeps us cool. It is strong yet flexible and able to heal and self-generate. It allows us to sense and respond in direct relation to environmental signals (e.g. sight, scent, taste, thought, emotion). It provides us with a physical image of self.

Integumentary System and ECS-Based Interactions

A multi-institutional study (2009) with researchers from Germany, the United States, England, and Hungary identified the presence of an abundant presence of ECS-modulated receptor sites (CB1, CB2) in the skin for possible targeted approaches in the treatment of various skin diseases. It concluded that the main function of the presence of the ECS in the skin is to control and balance growth, differentiation (the process of becoming a specific skin cell), and survival of skin cells as well as to produce proper immune responses. As such these researchers posit that the specific manipulation of the ECS might be beneficial in a multitude of human skin diseases including acne, dermatitis, dry skin, hair loss (alopecia, effluvium), hirsutism (excessive hair growth), itching, seborrhea, skin tumors, pain, and psoriasis for example.

Integumentary System Medical Specialists


Also Known As:

Exocrine System

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.