Nausea and Vomiting – Cannabis THC : CBD Ratios

Nausea and Vomiting Research Dashboard

46

Primary Studies

31

Related Studies

77

Total Studies

Clinical Studies

20

Double-blind human trials

6

Clinical human trials

Pre-Clinical Studies

17

Meta-analyses/Reviews

3

Animal studies

0

Laboratory studies

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CannaKeys has 77 studies associated with Nausea and Vomiting.

Here is a small sampling of Nausea and Vomiting studies by title:


Components of the Nausea and Vomiting Research Dashboard

  • Dosing information available for Nausea and Vomiting
  • Chemotype guidance for treating Nausea and Vomiting with cannabis
  • Synopsis of cannabis research for Nausea and Vomiting
  • Individual study details for Nausea and Vomiting

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Overview - Nausea and Vomiting

Description of Nausea and Vomiting

Vomiting involves involuntary but coordinated contractions of the stomach, respiratory, and esophageal muscles to forcefully eject the stomach's contents through the mouth or nose. Vomiting may occur as an autonomic response to the body's detection of poisons. Vomiting may also be induced voluntarily by stimulating the gag reflex through touch to the uvula or by taking an emetic (a substance that induces vomiting such as ipecac). Thus, vomiting can be a self-preservation mechanism; a self-induced evacuation of stomach content; or be brought on by disease, poison, severe fear, hormonal changes, or injury for example. Nausea and vomiting are also common occurrences following chemotherapy, as the toxic pharmacological agents do not differentiate between cancer cells and healthy cells. Retching and vomiting occur as a result of toxins detected by the brain. A signal travels from the vomiting center (area postrema), down cranial nerves, salivary glands, and diaphragmatic and gastrointestinal muscles, which initiates vomiting.

Disease Classification

Condition: Nausea and Vomiting
Disease Family: Gastrointestinal Condition
Organ System: Digestive System
ICD-10 Chapter: Symptoms, Signs and Abnormal Clinical and Laboratory Findings
ICD-10 Code: R11

Nausea and Vomiting Symptoms:

Upset stomach (e.g. feeling squeezy, anticipation of vomiting), mouth full of saliva, gagging, retching, involuntary diaphragmatic contractions, forcibly ejecting stomach content (throwing up), feeling anxious, bitter/sour taste in mouth

Also known as:

N/V, Bilious vomiting, Projectile vomiting

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.