Cannabis Hyperemesis Syndrome – Cannabis THC : CBD Ratios

Cannabis Hyperemesis Syndrome Research Dashboard

108

Primary Studies

4

Related Studies

112

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

108

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 112 studies associated with Cannabis Hyperemesis Syndrome.

Here is a small sampling of Cannabis Hyperemesis Syndrome studies by title:


Components of the Cannabis Hyperemesis Syndrome Research Dashboard

  • Dosing information available for Cannabis Hyperemesis Syndrome
  • Chemotype guidance for treating Cannabis Hyperemesis Syndrome with cannabis
  • Synopsis of cannabis research for Cannabis Hyperemesis Syndrome
  • Individual study details for Cannabis Hyperemesis Syndrome

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Overview - Cannabis Hyperemesis Syndrome

Description of Cannabis Hyperemesis Syndrome

Cannabinoid hyperemesis syndrome [distinct from cyclical vomiting syndrome (CVS)] is a relatively rare condition characterized by incessant abdominal discomforts, nausea, and vomiting that is relieved by taking hot showers. The reason for these symptoms are presently unclear and subject to ongoing research. A number of hypotheses have been proposed including achieving a causative tolerance, interference with the body's temperature mechanism, and the potential presence of various pesticides or chemical residue.

Disease Classification

Condition: Cannabis Hyperemesis Syn.
Disease Family: Toxic Exposure
Organ System: Mental/Emotional System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F12.188

Cannabis Hyperemesis Syndrome Symptoms:

Persistant nausea/vomiting (relieved by long hot showers), abdominal pain, dehydration, weightloss, renal failure

Also known as:

CHC

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.