Vitamin D Research Dashboard
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To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 6 studies associated with Vitamin D.
Here is a small sampling of Vitamin D studies by title:
- Cannabidiol (CBD) Upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines.
- Effects of Cannabidiol Interactions with CYP2R1, CYP27B1, CYP24A1, and Vitamin D3 Receptors on Spatial Memory, Pain, Inflammation, and Aging in Vitamin D3 Deficiency Diet-Induced Rats
- Cannabidiol improves thyroid function via modulating vitamin D3 receptor in vitamin D3 deficiency diet-induced rat model
- Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish
- Cannabidiol and Vitamin D3 Impact on Osteogenic Differentiation of Human Dental Mesenchymal Stem Cells
Components of the Vitamin D Research Dashboard
- Top medical conditions associated with Vitamin D
- Proven effects in clinical trials for Vitamin D
- Receptors associated with Vitamin D
- Individual study details for Vitamin D
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Overview - Vitamin D
Description of Vitamin D
Vitamin D: Forms, Function, and Health Relevance: Vitamin D refers to a group of fat-soluble steroid compounds essential for maintaining various physiological functions. The two most relevant forms for human health are vitamin D₂ (ergocalciferol) and vitamin D₃ (cholecalciferol).
Both D₂ and D₃ are found in relatively few natural food sources, including fish liver oil, egg yolks, mushrooms, and cheese. However, the primary source of vitamin D₃ for most people is synthesis in the skin, triggered when ultraviolet B (UVB) rays from sunlight interact with cholesterol precursors in skin cells.
Importantly, the vitamin D our body obtains—whether from diet, supplements, or sunlight—is initially inactive. To become biologically useful, it must undergo two activation steps (hydroxylation):
- In the liver, where it is converted into calcidiol (25-hydroxyvitamin D).
- In the kidneys, where it becomes calcitriol (1,25-dihydroxyvitamin D)—the active hormone form.
Once activated, vitamin D plays a vital role in enhancing calcium absorption in the gut and regulating calcium and phosphate balance—both essential for healthy bones and muscle function. A deficiency in vitamin D can lead to soft or fragile bones, muscle cramps, and increased risk of falls or fractures, especially in older adults. Severe deficiency can cause rickets in children or osteomalacia in adults.
According to the National Institutes of Health (NIH, 2023), vitamin D deficiency has also been associated with broader health concerns, including osteoporosis, cardiovascular disease (CVD), cancer, depression, multiple sclerosis (MS), type 2 diabetes, and impaired weight regulation.
Emerging Research Highlight: A four-year study found that taking 2,000 IU of vitamin D₃ daily significantly slowed the shortening of telomeres—the protective caps on our DNA that shorten with age—by approximately 140 base pairs. This suggests that vitamin D₃ supplementation, with or without omega-3 fatty acids, may help slow cellular aging and support genomic stability (H. Zhu et al., 2025).
Other Names:
CalciferolCalciferol, ergocalciferol (D2), cholecalciferol (D3)
Vitamin D Properties and Effects
Only Members can view Properties and Effects information. See DEMO page.
Vitamin D Receptor Binding
Only Members can view Receptor Binding information. See DEMO page.
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
