Virodhamine (O-AEA) Cannabinoid Research

Virodhamine (O-AEA) Research Dashboard

12

Primary Studies

23

Related Studies

35

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

0

Animal studies

10

Laboratory studies

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CannaKeys has 35 studies associated with Virodhamine (O-AEA).

Here is a small sampling of Virodhamine (O-AEA) studies by title:


Components of the Virodhamine (O-AEA) Research Dashboard

  • Top medical conditions associated with Virodhamine (O-AEA)
  • Proven effects in clinical trials for Virodhamine (O-AEA)
  • Receptors associated with Virodhamine (O-AEA)
  • Individual study details for Virodhamine (O-AEA)

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Overview - Virodhamine (O-AEA)

Description of Virodhamine (O-AEA)

Virodhamine is an endocannabinoid that was discovered in by researchers at Eli Lily and Co. (Amy Porter el al. 2002).

Other Names:

Virodhamine
O-arachidonoyl-ethanolamine, O-Arachidonoylethanolamine, Arachidonic Acid-(2-aminoethyl)-ester; (plus numerous other syn.)

Molecular Formula: C22H37NO2

IUPAC Name: 2-aminoethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate

Source–PubChem

Virodhamine (O-AEA) Properties and Effects

• O-AEA produce hypothermia in test animals (Amy Porter el al., 2002).
• O-AEA induces anti-depressive effects in nicotine dependent test animals (Tamaki Hayase, 2008)
• O-AEA relaxes the human pulmonary artery (H. Kozłowska et al., 2008).
• O-AEA is involved in regulating blood pressure and cardiovascular function (Lauren N. Carnevale et al., 2018).
• O-AEA activate GTPgammaS (GTPγS) binding via GPR55 (E. Ryberg et al., 2007).
• O-AEA is an agonist at PPAR alpha and increase PPAR alpha-driven transcriptional activity (Y. Sun et al., 2007)

Virodhamine (O-AEA) Receptor Binding

Endocannabinoid system (ECS)
• CB1 partial agonist with in vivo antagonist activity (Amy Porter el al., 2002).
• CB2 full agonist (Amy Porter el al., 2002).
• In the periphery O-AEA concentrations were 2- to 9-fold higher than AEA (Amy Porter el al., 2002).

Endocannabinoidome (eCBome)
• PPAR-Gamma
• PPAR-alpha
• GPR-55

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.