Zoster – Cannabis Research

Zoster Research Dashboard

1

Primary Studies

11

Related Studies

12

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

1

Animal studies

0

Laboratory studies

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CannaKeys has 12 studies associated with Zoster.

Here is a small sampling of Zoster studies by title:


Components of the Zoster Research Dashboard

  • Dosing information available for Zoster
  • Chemotype guidance for treating Zoster with cannabis
  • Synopsis of cannabis research for Zoster
  • Individual study details for Zoster

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Overview - Zoster

Description of Zoster

Varicella zoster is the same contagious virus that causes chickenpox (varicella). After the initial infection heals the virus remains dormant and in suseptible individuals may flare up later in life as shingles. The infection expresses itself in either an acute or chronic form. While blister formations can affect any part of the body most commonly it wrapps around the torso and can cause significant pains and discomforts. Complications include the development of postherpetic neuralgia i.e., chronic pains in the previously affected areas long after the leisons have disappeared. People with a compromised immune system are significantly more vulnerable to develop herpes zoster.

Disease Classification

Condition: Shingles
Disease Family:
Organ System: Integumentary System
ICD-10 Chapter: Certain infectious and parasitic diseases
ICD-10 Code: B02.9

Zoster Symptoms:

Blister formation, pain (can be severe), burning sensation, itching, reddening especially around the edge of the blisters, blister will eventually break ooze fluids and crust over, hyperalgesia (an increased response to noxious stimulus), allodynia (an unusual pain response to a normal stimulus), partial or complete loss of sensation, loss of quality of life, fever, headache, photophobia, weakness, if infections spreads to eyes it can cause significant damage.

Also known as:

Herpes zoster, varicella-zoster virus (VZV), human alphaherpesvirus (HHV-3)

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.