Vaping Injury (EVALI) – Cannabis THC : CBD Ratios

Vaping injury (EVALI) Research Dashboard

9

Primary Studies

0

Related Studies

9

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

9

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 9 studies associated with Vaping injury (EVALI).

Here is a small sampling of Vaping injury (EVALI) studies by title:


Components of the Vaping injury (EVALI) Research Dashboard

  • Dosing information available for Vaping injury (EVALI)
  • Chemotype guidance for treating Vaping injury (EVALI) with cannabis
  • Synopsis of cannabis research for Vaping injury (EVALI)
  • Individual study details for Vaping injury (EVALI)

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Overview - Vaping injury (EVALI)

Description of Vaping injury (EVALI)

Since the begining of 2020, the CDC had tracked an excess of 2800 cases of EVALI with 68 confirmed deaths in the US alone. As such, the CDC issued a description of EVALI (2019) to diagnose e-cigarette or vaping products associated lung injuries (EVALI).

Disease Classification

Condition: Vaping injury (EVALI)
Disease Family:
Organ System: Respiratory System
ICD-10 Chapter: Codes for special purposes
ICD-10 Code: U07.0

Vaping injury (EVALI) Symptoms:

Cough, fever, hemoptysis (bloody sputum), abdominal pain, nausea and vomiting, diarrhea, shortness of breath, weight loss, pulmonary embolism, renal infarction, superficial venous thrombosis (potentially secondary to broad spread of inflammation)

Also known as:

E-cigarette, or vaping associated lung injury, electronic cigarette related lung injury, electronic cigarette related lung damage, dabbing related lung damage, dabbing related lung injury, acute respiratory distress syndrome (ARDS), acute lung injury, drug-induced interstitial lung disorder, lipoid pneumonia, EVALI, vaping injury

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.