Status Epilepticus Research Dashboard
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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 22 studies associated with Status Epilepticus.
Here is a small sampling of Status Epilepticus studies by title:
- Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and Cannabinoids 1 (CB1), But Not CB2 and GABAA Receptors
- Myoclonic super-refractory status epilepticus with favourable evolution in a teenager with FIRES: Is the association of vagus nerve stimulation and cannabidiol effective?
- Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats
- Cannabidiol in refractory status epilepticus: A review of clinical experiences
- High dose cannabidiol (CBD) in the treatment of new-onset refractory status epilepticus (NORSE)
Components of the Status Epilepticus Research Dashboard
- Dosing information available for Status Epilepticus
- Chemotype guidance for treating Status Epilepticus with cannabis
- Synopsis of cannabis research for Status Epilepticus
- Individual study details for Status Epilepticus
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Overview - Status Epilepticus
Description of Status Epilepticus
Status Epilepticus (SE) is a neurological emergency characterized by a prolonged seizure lasting more than 5 minutes or repeated seizures without a return to baseline consciousness between episodes. Unlike typical epileptic seizures, which are usually self-limiting and last only 1-2 minutes, SE is continuous and requires immediate medical intervention to prevent brain damage, systemic complications, or death.
SE can be triggered by several factors, including discontinuation or sub-therapeutic levels of anti-epileptic drugs, brain injuries such as stroke or trauma, central nervous system infections like meningitis, metabolic disturbances (e.g., hypoglycemia, electrolyte imbalances), alcohol or drug withdrawal, and underlying chronic epilepsy. In children, fever-related seizures or genetic conditions can also cause SE. Identifying and treating the underlying cause is crucial in effectively managing this true emergency.
There are two main types of SE: convulsive and non-convulsive. Convulsive SE involves prolonged tonic-clonic seizures with visible convulsions, while non-convulsive SE involves altered mental status without significant motor symptoms, making it harder to recognize.
The critical difference between SE and other epilepsy types lies in duration and severity. While regular seizures can be part of a chronic epilepsy condition, SE is an acute, life-threatening condition. Quick treatment with medications like benzodiazepines, followed by anti-epileptics, is crucial to halt the seizures and mitigate the risk of long-term damage. However, in cases where the patient does not respond to standard anti-epileptics new and effective means remain wanting.
Disease Classification
Condition: Epilepsy - Status EpilepticusDisease Family:
Organ System: Nervous System
ICD-10 Chapter: Disease of the Nervous System
ICD-10 Code: G40.901
Status Epilepticus Symptoms:
Tonic-clonic convulsions involving rhythmic jerking and muscle stiffness, continuous seizure activity lasting more than 5 minutes, unresponsiveness or altered consciousness during and between seizures, foamy mucus in mouth, difficulty breathing or cyanosis (bluish skin), incontinence, oral trauma, risk of aspiration, if patient regains degree of consciousness it is typically associated with confusion or disorientation. Involuntary movements such as eye twitching or lip-smacking in non-convulsive SE. Possibly altered autonomic dysfunction like irregular heartbeat, sweating, or hyperthermia. If preceded by fall watch for signs of trauma.Also known as:
Status seizure, generalized convulsive status epilepticusDrug Interactions
THC Interaction with Pharmaceutical Drugs
- Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol.
- THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
- Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
CBD Interaction with Pharmaceutical Drugs
- Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
- Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.
If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
THC/CBD Interaction with Pharmaceutical Drugs
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
