Restless Leg Syndrome – Cannabis Research

Restless Leg Syndrome Research Dashboard


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CannaKeys has 6 studies associated with Restless Leg Syndrome.

Here is a small sampling of Restless Leg Syndrome studies by title:

Components of the Restless Leg Syndrome Research Dashboard

  • Dosing information available for Restless Leg Syndrome
  • Chemotype guidance for treating Restless Leg Syndrome with cannabis
  • Synopsis of cannabis research for Restless Leg Syndrome
  • Individual study details for Restless Leg Syndrome

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Overview - Restless Leg Syndrome

Description of Restless Leg Syndrome

Restless leg syndrome(RLS) is characterized by an uncontrollable need to move your legs when confronted with an uncomfortable or stressful mental-emotional experience. Moving or tapping the foot or feet to the floor when sitting or lying typically eases the emotional urge or discomforts. Within orthodox medicine the precise causation is still subject to speculation and inquiry and may include nutritional deficiencies (e.g. iron), the presence of other potentially contributing diseases (e.g. Parkinson’s Disease, multiple sclerosis, opioid withdrawal) or the use of certain pharmaceutical medication can make it worse (e.g. antipsychotics, antidepressants, certain antihistamines). One hypothesis considers an imbalance of the naturally occurring neurotransmitter dopamine is not considered to be related to other underlying more serious conditions. Trigger or contributing factors include the use of caffeine or nicotine.

Disease Classification

Condition: Restless Leg Syndrome
Disease Family:
Organ System: Nervous System
ICD-10 Chapter: Diseases of the nervous system
ICD-10 Code: G25

Restless Leg Syndrome Symptoms:

Symptoms more commonly occur at times of rest or relaxation and occur on a spectrum between mild annoyances and severe disturbances in quality of life such as: urge to move extremities, jerking movements in the legs, restlessness, tossing and turning, disturbed ability to rest and sleep at night (e.g. ruminating, insomnia).

Also known as:

Willis-Ekbom disease, Restless Legs Syndrome, RLS

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.