Restless Leg Syndrome Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 11 studies associated with Restless Leg Syndrome.
Here is a small sampling of Restless Leg Syndrome studies by title:
- Updates in the use of cannabis for insomnia
- The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Post Hoc Exploratory Analysis of Phase 2/3 Clinical Trial
- Cannabis for Restless Legs Syndrome
- Cannabis Use for Restless Legs Syndrome and Uremic Pruritus in in patients treated with maintenance dialysis: A Survey
- More evidence of cannabis efficacy in restless legs syndrome
Components of the Restless Leg Syndrome Research Dashboard
- Dosing information available for Restless Leg Syndrome
- Chemotype guidance for treating Restless Leg Syndrome with cannabis
- Synopsis of cannabis research for Restless Leg Syndrome
- Individual study details for Restless Leg Syndrome
Ready to become a subscriber? Go to our PRICING page.
Restless Leg Syndrome Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 11 studies associated with Restless Leg Syndrome.
Here is a small sampling of Restless Leg Syndrome studies by title:
- Updates in the use of cannabis for insomnia
- The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Post Hoc Exploratory Analysis of Phase 2/3 Clinical Trial
- Cannabis for Restless Legs Syndrome
- Cannabis Use for Restless Legs Syndrome and Uremic Pruritus in in patients treated with maintenance dialysis: A Survey
- More evidence of cannabis efficacy in restless legs syndrome
Components of the Restless Leg Syndrome Research Dashboard
- Dosing information available for Restless Leg Syndrome
- Chemotype guidance for treating Restless Leg Syndrome with cannabis
- Synopsis of cannabis research for Restless Leg Syndrome
- Individual study details for Restless Leg Syndrome
Ready to become a subscriber? Go to our PRICING page.
Select New Condition
Overview - Restless Leg Syndrome
Description of Restless Leg Syndrome
Restless leg syndrome (RLS) is characterized by an uncontrollable need to move your legs when confronted with an uncomfortable or stressful mental-emotional experience. Moderate-to-severe RLS affects roughly 3% of North American and European populations. Moving or tapping the foot or feet to the floor when sitting or lying typically eases the emotional urge or discomforts. RLS presents a considerable obstacle to sleep, quality of life, and is associated with significant morbidity.
Within orthodox medicine, the precise cause is still subject to speculation and inquiry. Potential causes may include nutritional deficiencies (i.e., iron), the presence of other potentially contributing diseases (e.g., Parkinson’s Disease, multiple sclerosis, opioid withdrawal). The use of certain pharmaceutical medications can make it worse (e.g., antipsychotics, antidepressants, certain antihistamines).
One hypothesis considers an imbalance of the naturally occurring neurotransmitter dopamine. This dopamine imbalance may not necessarily be related to another underlying, more serious condition. Triggering or contributing factors include the use of caffeine or nicotine.
Typical prescriptions for RLS include dopamine agonists (DA), anticonvulsants, or even opiates (historically). Given alone or in combination, RLS patients may still have refractory symptoms. Physical activity may temporarily improve symptoms. In 2014, the FDA approved a new device for improving sleep in RLS patients.
Disease Classification
Condition: Restless Leg SyndromeDisease Family:
Organ System: Nervous System
ICD-10 Chapter: Diseases of the nervous system
ICD-10 Code: G25
Restless Leg Syndrome Symptoms:
Symptoms more commonly occur at times of rest or relaxation and occur on a spectrum between mild annoyances and severe disturbances in quality of life such as: urge to move extremities, jerking movements in the legs, restlessness, tossing and turning, disturbed ability to rest and sleep at night (e.g., ruminating, insomnia). In severe cases, these disruptions can leave patients with daytime sleepiness and the many health consequences of insufficient sleep.Also known as:
Willis-Ekbom disease, Restless Legs Syndrome, RLSDrug Interactions
THC Interaction with Pharmaceutical Drugs
- Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol.
- THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
- Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
CBD Interaction with Pharmaceutical Drugs
- Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
- Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.
If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
THC/CBD Interaction with Pharmaceutical Drugs
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
