Pregnancy Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 289 studies associated with Pregnancy.
Here is a small sampling of Pregnancy studies by title:
- Effects of prenatal cannabinoid use on the monoamine system in the fetoplacental unit: A systematic review of animal and human studies
- Cannabidiol exerts teratogenic effects on developing zebrafish through the sonic hedgehog signaling pathway
- Maternal Obesity and Excessive Gestational Weight Gain Influence Endocannabinoid Levels in Human Milk Across Breastfeeding: Potential Implications for Offspring Development
- Prenatal cannabinoid exposure affects central cardiorespiratory control in young male and female rats
- Placental Endocannabinoid System: Focus on Preeclampsia and Cannabis Use
Components of the Pregnancy Research Dashboard
- Dosing information available for Pregnancy
- Chemotype guidance for treating Pregnancy with cannabis
- Synopsis of cannabis research for Pregnancy
- Individual study details for Pregnancy
Ready to become a subscriber? Go to our PRICING page.
Pregnancy Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 289 studies associated with Pregnancy.
Here is a small sampling of Pregnancy studies by title:
- Effects of prenatal cannabinoid use on the monoamine system in the fetoplacental unit: A systematic review of animal and human studies
- Cannabidiol exerts teratogenic effects on developing zebrafish through the sonic hedgehog signaling pathway
- Maternal Obesity and Excessive Gestational Weight Gain Influence Endocannabinoid Levels in Human Milk Across Breastfeeding: Potential Implications for Offspring Development
- Prenatal cannabinoid exposure affects central cardiorespiratory control in young male and female rats
- Placental Endocannabinoid System: Focus on Preeclampsia and Cannabis Use
Components of the Pregnancy Research Dashboard
- Dosing information available for Pregnancy
- Chemotype guidance for treating Pregnancy with cannabis
- Synopsis of cannabis research for Pregnancy
- Individual study details for Pregnancy
Ready to become a subscriber? Go to our PRICING page.
Select New Condition
Overview - Pregnancy
Description of Pregnancy
Pregnancy is a remarkable biological journey that begins the moment an egg and sperm unite, creating a single cell known as a zygote. Within days, this new life divides repeatedly and travels down the fallopian tube toward the uterus. Once there, it implants into the uterine wall at the very site where the placenta will soon begin to form, establishing the vital connection that will nourish and protect the developing baby. From that point, gestation unfolds over roughly 40 weeks, traditionally divided into three trimesters, each bringing its own milestones for the developing baby and adaptations for the mother.
In the first trimester, rapid and delicate steps in development occur. The basic blueprint for every major organ is laid down, the heart begins to beat, and the placenta starts forming. Hormones such as human chorionic gonadotropin (hCG) and progesterone rise sharply, often causing fatigue, breast changes, and morning sickness—a wave of nausea that can strike at any time of day, but most often occurs in the morning and is most common between weeks 6 and 14.
During the second trimester, the fetus grows steadily as organs refine their functions. Bones harden, sensory abilities like hearing emerge, and many mothers feel the first flutters of movement. This stage is often physically easier for the mother, and detailed ultrasounds are commonly performed to check growth and anatomy.
By the third trimester, the focus shifts to readiness for life outside the womb. The baby’s lungs mature, brain development accelerates, and body fat builds up for warmth after birth. Meanwhile, the mother’s body prepares for labor through cervical changes and Braxton Hicks contractions—irregular, usually painless tightenings of the uterus that act as “practice” contractions without indicating true labor.
Pregnancy is a also dynamic interplay between two interconnected beings—mother and child—and benefits from attentive prenatal care. Monitoring health, fostering development, and addressing any complications help ensure a safe and healthy start to life.
Disease Classification
Condition: PregnancyDisease Family: Health and Well Being
Organ System: Reproductive System
ICD-10 Chapter: Pregnancy, Childbirth and the Puerperium
ICD-10 Code: O00-O48
Pregnancy Symptoms:
Hormonal shifts, including rising levels of hCG and progesterone, often result in symptoms such as fatigue, nausea (morning sickness), back pain, breast tenderness, changes in eating habits, increased need for urination, heartburn, hemorrhoids, nipple changes (e.g., darker, enlarged), and stretch marks.Also known as:
Parturiency, Child-bearing, GravidityDrug Interactions
THC Interaction with Pharmaceutical Drugs
- Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol.
- THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
- Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
CBD Interaction with Pharmaceutical Drugs
- Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
- Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.
If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
THC/CBD Interaction with Pharmaceutical Drugs
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
