Parkinson's Disease Research Dashboard
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To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 166 studies associated with Parkinson's Disease.
Here is a small sampling of Parkinson's Disease studies by title:
- Inhibition of anandamide hydrolysis does not rescue respiratory abnormalities observed in an animal model of Parkinson's disease
- Cannabis use in Parkinson's disease-A nationwide online survey study
- Effects of Cannabis in Parkinson's Disease: A Systematic Review and Meta-Analysis
- Higher Risk, Higher Reward? Self‐Reported Effects of Real‐World Cannabis Use in Parkinson's Disease
- Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty
Components of the Parkinson's Disease Research Dashboard
- Dosing information available for Parkinson's Disease
- Chemotype guidance for treating Parkinson's Disease with cannabis
- Synopsis of cannabis research for Parkinson's Disease
- Individual study details for Parkinson's Disease
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Overview - Parkinson's Disease
Description of Parkinson's Disease
Western medicine considers Parkinson's disease a chronic degenerative brain/nervous system disorder. An estimated 50,000 new cases of Parkinson's arise in the U.S. every year. Scientists believe that this degenerative disease results from the loss of specific nerve cells that produce the chemical dopamine (a naturally occurring neurotransmitter). Orthodox medicine does not have a cure and treatment is mostly limited to pharmaceutical interventions (e.g. levodopa).Disease Classification
Condition: Parkinson's DiseaseDisease Family: Neurological Condition
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G20
Parkinson's Disease Symptoms:
Shaking extremities, blank expressions, loss of balance, stiffness, shuffling steps, difficulty swallowing, insomnia, emotional problemsAlso known as:
PD, Parkinsonism, Restrictive lung mechanics due to parkinsons disease, Dementia in parkinsons diseaseDrug Interactions
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
