Organ Transplant/Graft Rejection/Failure Research Dashboard
Double-blind human trials
Clinical human trials
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CannaKeys has 22 studies associated with Organ Transplant/Graft Rejection/Failure.
Here is a small sampling of Organ Transplant/Graft Rejection/Failure studies by title:
- The Impact of Marijuana Use on Liver Transplant Recipients: A 900 Patient Single Center Experience
- Marijuana Use Among Adult Liver Transplant Candidates and Recipients
- Epidemiology of cannabis use and associated outcomes among kidney transplant recipients: A meta-analysis
- Cannabidiol Enhances Intestinal Cannabinoid Receptor Type 2 Receptor Expression and Activation Increasing Regulatory T Cells and Reduces Murine Acute Graft-versus-Host Disease without Interfering with the Graft-versus-Leukemia Response
- Cannabis Dependence or Abuse in Kidney Transplantation: Implications for Posttransplant Outcomes
Components of the Organ Transplant/Graft Rejection/Failure Research Dashboard
- Dosing information available for Organ Transplant/Graft Rejection/Failure
- Chemotype guidance for treating Organ Transplant/Graft Rejection/Failure with cannabis
- Synopsis of cannabis research for Organ Transplant/Graft Rejection/Failure
- Individual study details for Organ Transplant/Graft Rejection/Failure
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Overview - Organ Transplant/Graft Rejection/Failure
Description of Organ Transplant/Graft Rejection/Failure
Transplant rejection occurs when cells of the immune system reject the new organs, cells or tissue. Allopathic treatment includes immunosuppressive pharmaceutical drugs. However, the chronic applications of these drugs results can also result in major complications for the receiving patients making novel approaches a pressing matter.
Organ Transplant Failure
Injury, Poisoning and Certain Other Consequences of External Causes
ICD-10 Code: T86
Organ Transplant/Graft Rejection/Failure Symptoms:
Localized inflammation (red, swelling, pain) at site of organ or graft, fever, generalized weakness, flu-like symptoms, may progress to sepsis
Also known as:
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.