Nervous System – Cannabis and Cannabinoid Research

Nervous System Research Dashboard

1258

Primary Studies

246

Related Studies

1504

Total Studies

Clinical Studies

104

Double-blind human trials

98

Clinical human trials

Pre-Clinical Studies

608

Meta-analyses/Reviews

371

Animal studies

77

Laboratory studies

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CannaKeys has 1504 studies associated with Nervous System.

Here is a small sampling of Nervous System studies by title:


Components of the Nervous System Research Dashboard

  • Medical conditions associated with Nervous System
  • Synopsis of cannabis research for Nervous System
  • Chemotype guidance for Nervous System
  • Individual study details for Nervous System

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Overview - Nervous System

Description of Nervous System

The nervous system functions to transmit internal and external environmental signals and it is comprised of a number of divisions or sub-systems such as the central nervous system (i.e. brain, spinal cord, the five senses) and the peripheral nervous system (with autonomic, enteric, and somatic/voluntary divisions). The autonomic nervous system is further divided into sympathetic (i.e. fight, flight, freeze) and parasympathetic (rest, digest, and repair) nervous system. In healthy individuals all systems work in tandem toward homeostasis allowing the entire body to live and thrive, to love and learn.

Nervous System and ECS-Based Interactions

Endocannabinoid receptor sites (e.g. CB1 and CB2) are abundantly present in all parts of the nervous system. In fact, CB1 receptor sites are the most abundant G-protein coupled receptor expressed in the CNS (i.e. the brain and spinal cord). CB2 receptor sites are more abundantly present in the peripheral nervous system and in cells of the immune system and as such support complex immune responses (e.g. pro- and anti-inflammatory cytokine production). Both CB1 and CB2 participate in a great variety of life sustaining effects that allow us to live and thrive such as motor control, cognition, emotional responses, motivation, and neurological homeostasis for example.

Nervous System Medical Specialists

Neurologist, Neuropathologist, Neurophysiologist, Neuropath, Neuropathist, Ontologist, Ophthalmologist

Also Known As:

N/A

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.