Nausea and Vomiting – Cannabis Research

Nausea and Vomiting Research Dashboard


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CannaKeys has 269 studies associated with Nausea and Vomiting.

Here is a small sampling of Nausea and Vomiting studies by title:

Components of the Nausea and Vomiting Research Dashboard

  • Dosing information available for Nausea and Vomiting
  • Chemotype guidance for treating Nausea and Vomiting with cannabis
  • Synopsis of cannabis research for Nausea and Vomiting
  • Individual study details for Nausea and Vomiting

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Overview - Nausea and Vomiting

Description of Nausea and Vomiting

Vomiting involves involuntary but coordinated contractions of the diaphragm, abdominal, thoracic, and esophageal muscles to forcefully eject the stomach's contents through the mouth or nose. Vomiting may occur as an autonomic response to the body's detection of poisons. Vomiting may also be induced voluntarily by stimulating the gag reflex through touch to the uvula or by taking an emetic (a substance that causes vomiting, such as ipecac).

Vomiting can be a self-preservation mechanism; a self-induced evacuation of stomach content; or be brought on by disease, poison, severe fear, hormonal changes, or injury. Nausea and vomiting are common occurrences following chemotherapy, as the toxic pharmacological agents do not differentiate between cancer and healthy cells. Retching and vomiting occur as a result of toxins detected by the brain. A signal travels from the vomiting center (area postrema) down cranial nerves, salivary glands, and diaphragmatic and gastrointestinal muscles, which initiates vomiting.

However, prolonged or uncontrolled vomiting can not only be debilitating but be life-threatening due to the risk of dehydration, electrolyte disturbances, aspiration of gastric contents, muscle tears, internal bleeding, and eventually end-organ failure if left untreated. Ingesting excessive levels of cannabinoids, primarily THC, is ironically associated with inducing nausea and vomiting that may be prolonged.

This is called cannabinoid hyperemesis syndrome (CHS) and is covered in the CHS section of the CK platform. This happens because cannabinoids can have biphasic effects, meaning their properties can change or oppose each other based on the patient's given concentration, dose, and subjective sensitivity.

Disease Classification

Condition: Nausea and Vomiting
Disease Family: Gastrointestinal Condition
Organ System: Digestive System
ICD-10 Chapter: Symptoms, Signs and Abnormal Clinical and Laboratory Findings
ICD-10 Code: R11

Nausea and Vomiting Symptoms:

Upset stomach (e.g., feeling queasy, the anticipation of vomiting), mouth full of saliva, gagging, retching, involuntary diaphragmatic contractions, forcibly ejecting stomach content (throwing up), feeling anxious, bitter or sour taste in the mouth.

Also known as:

N/V, Bilious vomiting, Projectile vomiting

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol. 
  • THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
  • Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: or DrugBank Online.

CBD Interaction with Pharmaceutical Drugs

  • Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
  • Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.

If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: or DrugBank Online.

THC/CBD Interaction with Pharmaceutical Drugs

In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.

If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: or DrugBank Online.

Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).

However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.