Muscular System – Cannabis and Cannabinoid Research

Muscular System Research Dashboard


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CannaKeys has 171 studies associated with Muscular System.

Here is a small sampling of Muscular System studies by title:

Components of the Muscular System Research Dashboard

  • Medical conditions associated with Muscular System
  • Synopsis of cannabis research for Muscular System
  • Chemotype guidance for Muscular System
  • Individual study details for Muscular System

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Overview - Muscular System

Description of Muscular System

The muscular system is comprised of 320 pairs of individual muscles (total 640) most of which are mirror images of each other as they populate both sides of the body. They can be divided into three categories: smooth muscles (e.g. those that constrict and dilate arteries/veins, promote the movement of chime, or allow us to breathe), skeletal muscles which allow us to interact with the physical environment, and cardiac muscles. There are a number of distinct difference and abilities between these three. For instance, only cardiac muscles have the ability to start working together in concert after suffering a cardiac arrest and being subsequently reanimated by electroshock (defibrillation) a process called automaticity. All skeletal muscles are subject to conscious control (while both smooth and cardiac muscles are mostly not). Smooth muscles are void of striation (thus the name) allowing them to stretch to greater length without risking rupture (at least compared to cardiac and skeletal muscles).

Muscular System and ECS-Based Interactions

To date we have very little actionable information about cannabinoids and cannabinoid receptor sites in skeletal muscle tissue. However, research has found endocannabinoid receptors (CB1) in skeletal muscles (i.e. gastrocnemius, rectus abdominis). CB1 and CB2 receptors were detected in human facial fascia (dense connective tissue surrounding facial muscles). And, CB2 have been found in the muscles of the heart and in smooth muscle cells.

Muscular System Medical Specialists

Orthopedist, Neurologist, Osteopath, Chiropractor

Also Known As:


Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.