Menstrual Pain and Associated Conditions – Cannabis Research

Menstrual Pain and Associated Conditions Research Dashboard

12

Primary Studies

33

Related Studies

45

Total Studies

Clinical Studies

1

Clinical Meta-analyses

1

Double-blind Clinical Trials

1

Clinical Trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

2

Animal Studies

1

Laboratory Studies

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To see a full dashboard with study details and filtering, go to our DEMO page.

As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 45 studies associated with Menstrual Pain and Associated Conditions.

Here is a small sampling of Menstrual Pain and Associated Conditions studies by title:


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Cannabis for Chronic Pain Relief A dual Guide for Clinicians and Patients - a paperback book published by CannaKeys

Cannabis for Chronic Pain Relief: A Dual Guide for Patients and Clinicians

A practical, evidence-based guide to using cannabis and cannabinoids for chronic pain.

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Menstrual Pain and Associated Conditions Research Dashboard

12

Primary Studies

33

Related Studies

45

Total Studies

Clinical Studies

1

Clinical Meta-analyses

1

Double-blind Clinical Trials

1

Clinical Trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

2

Animal Studies

1

Laboratory Studies

What am I missing as a non-subscriber?

To see a full dashboard with study details and filtering, go to our DEMO page.

As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 45 studies associated with Menstrual Pain and Associated Conditions.

Here is a small sampling of Menstrual Pain and Associated Conditions studies by title:


Ready to become a subscriber? Go to our PRICING page. Want to learn more about Endocannabinoid Medicine? Buy a book.

Endocannabinoid Medicine 11 Keys to Deeper Healing paperback book published by CannaKeys

Endocannabinoid Medicine: 11 Keys to Deeper Healing

A clear, science-based guide to working with the endocannabinoid system for whole-body balance.

Buy Book
Cannabis for Chronic Pain Relief A dual Guide for Clinicians and Patients - a paperback book published by CannaKeys

Cannabis for Chronic Pain Relief: A Dual Guide for Patients and Clinicians

A practical, evidence-based guide to using cannabis and cannabinoids for chronic pain.

Buy Book

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Overview - Menstrual Pain and Associated Conditions

Description of Menstrual Pain and Associated Conditions

The term menses, or menstruation, derives from the Latin word mensis, meaning “month.” The average menstrual cycle lasts about 28 days, which closely aligns with the lunar cycle, as the moon takes roughly the same time to wax and wane. At the end of each cycle, a woman’s body prepares for the possibility of pregnancy by regenerating the uterine lining. When fertilization does not occur, the body releases this lining through menstruation, resulting in the monthly discharge of blood and tissue. This process is a normal and essential part of reproductive health, hormonal rhythm, and physiological regulation.


As the body moves through these monthly shifts, it often carries the mind and emotions along with it. Energy may rise or fall, feelings may come closer to the surface, and perception can subtly change. For many women, menstruation is not only a physical rhythm, but an inner one as well—shaping mood, sensitivity, reflection, and emotional tone in quiet and deeply personal ways.


For many women, however, menstruation is not experienced as a neutral or gentle process. Menstrual difficulties are common and can show up in a variety of ways (see signs and symptoms). Physical discomfort is often accompanied by fatigue and a sense of weakness or depletion.


Menstrual challenges can also extend beyond the physical. Many women experience mood and emotional changes around their cycle, such as irritability, low mood, anxiety, or heightened emotional sensitivity—often described as premenstrual syndrome (PMS) or, in more severe cases, premenstrual dysphoric disorder (PMDD). Increased sensitivity to light, sound, or stress, along with sleep disturbances, can further compound the experience, sometimes contributing to headaches or migraines and making everyday demands feel harder to manage.


Lifestyle factors, past health history, cultural upbringing, individual beliefs, and environmental influences all play a role in shaping how the menstrual cycle is experienced.


When symptoms interfere with daily life, relationships, or overall quality of life, supportive medical guidance and individualized management strategies can help restore comfort, balance, and resilience.


Menstruation is a natural rhythm, but how it is lived in the body varies widely. Understanding and addressing menstrual difficulties is not about pathologizing the cycle, but about supporting the body so that this monthly process can unfold with as much ease, dignity, and resilience as possible.

Disease Classification

Condition: Menstrual Pain & Difficulties
Disease Family: Dysmenorrhea
Organ System: Reproductive System
ICD-10 Chapter: Diseases of the Genitourinary System
ICD-10 Code: N94

Menstrual Pain and Associated Conditions Symptoms:

Lower abdominal and pelvic pain (cramps, dysmenorrhea), heavy or dark menstrual bleeding (clots), pelvic pressure or aching, low back pain (cycle-related), bloating (abdominal fullness), gastrointestinal upset (nausea, diarrhea, constipation), fatigue (low energy, weakness), mood changes (irritability, low mood, anxiety), heightened sensory sensitivity (light, sound), headaches or migraines (menstrual-related), sleep disturbance (poor or non-restorative sleep)

Also known as:

Dysmenorrhea, menstrual cramps, menstrual pain, painful periods, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), premenstrual tension syndrome, ovulatory pain, mittelschmerz, pelvic pain (cyclic), chronic pelvic pain, dyspareunia, pain during intercourse, vaginismus, abnormal uterine bleeding

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol. 
  • THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
  • Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.

CBD Interaction with Pharmaceutical Drugs

  • Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
  • Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.

If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.

THC/CBD Interaction with Pharmaceutical Drugs

In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.

If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.

Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).

However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)
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Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.