Insomnia and Sleep Disorders – Cannabis Research

Insomnia and Sleep Disorders Research Dashboard


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CannaKeys has 162 studies associated with Insomnia and Sleep Disorders.

Here is a small sampling of Insomnia and Sleep Disorders studies by title:

Components of the Insomnia and Sleep Disorders Research Dashboard

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  • Chemotype guidance for treating Insomnia and Sleep Disorders with cannabis
  • Synopsis of cannabis research for Insomnia and Sleep Disorders
  • Individual study details for Insomnia and Sleep Disorders

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Overview - Insomnia and Sleep Disorders

Description of Insomnia and Sleep Disorders

Insomnia is difficulty or inability to fall or stay asleep. While many possible causes exist for insomnia, it is interesting to note that its preceding symptoms mirror the condition's effects. Depending on the severity, insomnia affects mental and physical performance as well as emotional expressions (sufferers become moody or irritable). Insomnia may produce symptoms of anxiety, depression, low energy and affect, fatigue, hallucinations, lowered immunity, and hormone disruption each with its own set of possible complications (i.e., hypertension or heart disease). Orthodox medicine's approach to insomnia includes diagnostics to determine underlying causes. Common pharmacological treatments for insomnia include psychoactive benzodiazepines such as Valium (can be addictive), sedative-hypnotic drugs like Ambien (can be addictive), opiates for the co-treatment of pain (can be addictive), and antidepressants (possible serious side effects). While these agents help manage the symptoms, none of these medications cure chronic insomnia, which usually returns once the medication is stopped.

Disease Classification

Condition: Insomnia
Disease Family: Deficiency (Sleep) Disorder
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G47.0-G47.2

Insomnia and Sleep Disorders Symptoms:

Difficulty falling asleep, difficulty staying asleep, morning drowsiness, ruminating, generalized weakness, irritability, depression, stress, chronic or acute (temporary),

Also known as:

Insomnia, Hypersomnia, Circadian rhythm sleep disorders, Narcolepsy, Cataplexy, Parasomnia, Sleep related movement disorders

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.