Insomnia and Sleep Disorders – Cannabis Research

Insomnia and Sleep Disorders Research Dashboard


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CannaKeys has 285 studies associated with Insomnia and Sleep Disorders.

Here is a small sampling of Insomnia and Sleep Disorders studies by title:

Components of the Insomnia and Sleep Disorders Research Dashboard

  • Dosing information available for Insomnia and Sleep Disorders
  • Chemotype guidance for treating Insomnia and Sleep Disorders with cannabis
  • Synopsis of cannabis research for Insomnia and Sleep Disorders
  • Individual study details for Insomnia and Sleep Disorders

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Overview - Insomnia and Sleep Disorders

Description of Insomnia and Sleep Disorders

The underlying causes for insomnia are often difficult to pinpoint and, as such, represent a challenge for the health care provider and patient alike. If the maintaining cause is not identified and removed, no matter what treatment is used, insomnia will remain a chronic issue.

Some causes, such as an uncomfortable bed, fluctuating work shifts, or a noisy sleep environment, are more easily identified and remedied than others.

Stress and anxiety are significant contributing factors to insomnia and can be more challenging to remedy. Here, in this context, physicians may recommend cognitive-behavioral therapies.

Co-morbidities, including chronic pain, mood disorders (e.g., schizophrenia, anxieties), heart or lung diseases, and several pharmaceutical medications can cause or contribute to insomnia.

Pharmaceutical prescription drugs for insomnia can cause significant adverse effects. There are concerns about addiction and developing a tolerance. And evidence-based data on the long-term effectiveness of prescription sleeping aids has produced mixed results. Common pharmacological treatments for insomnia include psychoactive benzodiazepines such as Valium (can be addictive), sedative-hypnotic drugs like Ambien (can be addictive), opiates for the co-treatment of pain (can be addictive), and antidepressants (possible severe side effects).

Depending on the severity, insomnia affects mental and physical performance and emotional expressions (sufferers become moody or irritable).

In addition, insomnia may produce or worsen already existing feelings of symptoms of anxiety, depression, low energy and affect, fatigue, hallucinations, lowered immunity, and hormone disruption, each with its own set of possible complications.

Disease Classification

Condition: Insomnia and Sleep Disorders
Disease Family: Deficiency (Sleep) Disorder
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G47.0-G47.2

Insomnia and Sleep Disorders Symptoms:

Difficulty falling asleep, difficulty staying asleep, morning drowsiness, ruminating, generalized weakness, irritability, depression, stress, chronic or acute (temporary),

Also known as:

Insomnia, Hypersomnia, Circadian rhythm sleep disorders, Narcolepsy, Cataplexy, Parasomnia, Sleep related movement disorders, alcohol-related insomnia, drug-related insomnia, idiopathic insomnia, insomnia due to a mental disorder, insomnia not due to a substance or known physiologic condition, non-organic insomnia, primary insomnia, unspecified insomnia, insomnia disorder, insomnia disorder related to known organic Factor, specific insomnia disorder, recurrent insomnia disorder, organic insomnia, insomnia not otherwise specified, adjustment insomnia, transient insomnia, psychophysiologic insomnia, persistent organic insomnia, maintaining sleep disorder, initiating sleep disorder, persistent organic initiating or maintaining sleep disorder, persistent organic sleep disorder, non-organic initiating sleep disorder, non-organic maintaining sleep disorder, non-organic initiating persistent sleep disorder, non-organic maintaining persistent sleep disorder, behavioral insomnia of childhood, persistent insomnia, insomnia due to a medical condition, hyposomnia due to Medical disorder, hyposomnia due to medical illness, insomnia co-occurrent and due to a medical condition, insomnia due to Medical Factor, insomnia due to nocturnal my appointments, sleep disorder due to a medical condition, hyposomnia, hyposomnia with Associated medical condition, insomnia due to known physiological condition, hyposomnia due to mental disorder, hyposomnia due to mental disorders, hyposomnia due to mental illness, hyposomnia due to physiological disorder, insomnia disorder related to another mental disorder, insomnia due to mental disorder, insomnia due to Associated mental disorder, paradoxical insomnia, fatal familial insomnia, combined type behavioral insomnia of childhood, limit setting type behavioral insomnia of childhood, sleep deprivation, lack of adequate sleep, inadequate sleep hygiene, irregular sleep habits, unhealthy sleepwick schedule, bad sleep habits

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol. 
  • THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
  • Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: or DrugBank Online.

CBD Interaction with Pharmaceutical Drugs

  • Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
  • Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.

If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: or DrugBank Online.

THC/CBD Interaction with Pharmaceutical Drugs

In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.

If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: or DrugBank Online.

Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).

However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.