Huntington’s Disease – Cannabis THC : CBD Ratios

Huntington's Disease Research Dashboard

25

Primary Studies

18

Related Studies

43

Total Studies

Clinical Studies

2

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

13

Animal studies

6

Laboratory studies

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CannaKeys has 43 studies associated with Huntington's Disease.

Here is a small sampling of Huntington's Disease studies by title:


Components of the Huntington's Disease Research Dashboard

  • Dosing information available for Huntington's Disease
  • Chemotype guidance for treating Huntington's Disease with cannabis
  • Synopsis of cannabis research for Huntington's Disease
  • Individual study details for Huntington's Disease

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Overview - Huntington's Disease

Description of Huntington's Disease

Huntington's disease (HD) or Huntington's chorea (abnormal twisting and writhing movements) is a degenerative genetic disease that affects the brain and nervous system, leading to loss of muscle control and dementia. A mutated form of the Huntington gene, found significantly more in Western Europeans, is thought to be responsible for disease development. No treatment exists within orthodox medicine for HD. However, to manage some of the disease complications, doctors may try certain treatments using a multidisciplinary approach composed of physical and speech therapies, neuroleptics (tranquilizing psychiatric pharmaceuticals), and other medication.

Disease Classification

Condition: Huntington's Disease
Disease Family: Neurological Disease
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G10

Huntington's Disease Symptoms:

Chorea (e.g. involuntary muscle twitching), dystonia (muscle contraction, twisting, and abnormal posturing), ataxia, aphasia, loss of coordination (e.g. abnormal eye movements), confusion, dementia, insomnia, mood disorders (e.g. depression), behavioral difficulties (e.g. lack of impulse control, social isolation).

Also known as:

HD, Huntington's chorea, Huntington's dementia

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.