Endocrine System – Cannabis and Cannabinoid Research

Endocrine System Research Dashboard

110

Primary Studies

52

Related Studies

162

Total Studies

Clinical Studies

5

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

50

Meta-analyses/Reviews

41

Animal studies

12

Laboratory studies

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CannaKeys has 162 studies associated with Endocrine System.

Here is a small sampling of Endocrine System studies by title:


Components of the Endocrine System Research Dashboard

  • Medical conditions associated with Endocrine System
  • Synopsis of cannabis research for Endocrine System
  • Chemotype guidance for Endocrine System
  • Individual study details for Endocrine System

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Overview - Endocrine System

Description of Endocrine System

This system is comprised of major glands including (from top to bottom) hypothalamus, pineal, pituitary, thyroid, thymus, adrenal, pancreas, ovary/testes each of which produces specific hormones that rapidly facilitate biological, psychological, and behavioral interactions. This system provides communication using hormones (and correlated emotions) to rapidly induce changes in physiology, psychology and behavior regarding the essential elements of human life ranging from fight, flight, freeze responses to the other side of the spectrum that is rest, digest, and repair and virtually everything in between.

Endocrine System and ECS-Based Interactions

Endocannabinoid receptors have been found in all major glands of the endocrine system: Hypothalamus (CB1), pineal (weak evidence for C1, CB2), pituitary (CB1), thyroid (CB1), thymus (CB2), adrenals (CB1), pancreas (CB1, CB2), and in the ovaries/testes (CB1). Glandular presence of cannabinoid receptors suggests a role in the function and effects produced by each of the glands individually and systemically. While the understanding of the interaction between the ECS and the endocrine system is in its infancy the most studied element between them is the modulation of stress via the hypothalamus, pituitary, adrenal (HPA) axis. And, since stress is arguably a major contributing factor in especially chronic degenerative conditions the impact of ECS-based modulation may play a significant role in mitigating chronic disease and inducing or increasing a state of well-being in body, mind, and emotion.

Endocrine System Medical Specialists

Endocrinologist

Also Known As:

N/A

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.