Dystonia & Related Conditions – Cannabis THC : CBD Ratios

Dystonia & Related Conditions Research Dashboard

10

Primary Studies

6

Related Studies

16

Total Studies

Clinical Studies

1

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

5

Meta-analyses/Reviews

3

Animal studies

0

Laboratory studies

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CannaKeys has 16 studies associated with Dystonia & Related Conditions.

Here is a small sampling of Dystonia & Related Conditions studies by title:


Components of the Dystonia & Related Conditions Research Dashboard

  • Dosing information available for Dystonia & Related Conditions
  • Chemotype guidance for treating Dystonia & Related Conditions with cannabis
  • Synopsis of cannabis research for Dystonia & Related Conditions
  • Individual study details for Dystonia & Related Conditions

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Overview - Dystonia & Related Conditions

Description of Dystonia & Related Conditions

The name dystonia a term that combines the Greek prefix ‘dys’ meaning difficult and the Latin ‘tonus’ relating degree of tonus of a muscle. Dystonia and related conditions are generally characterized by muscle spasms or other types of involuntary muscle movements such as tic or twitching (myoclonus) for example. Symptoms of dystonia can affect a single muscle (e.g. blepharospasm) or involve the whole body. Some forms of dystonia are related to other underlying medical condition such as Parkinson’s or Huntington’s disease. Other form can be caused by a number of pharmaceuticals such as phenothiazines a common group of antipsychotic drugs. Inherited forms that produce dystonia tend to produce whole body dystonia’s and distorted body postures.

Disease Classification

Condition: Dystonia
Disease Family: Nervous System Disorder
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G24.01

Dystonia & Related Conditions Symptoms:

Lip smacking, jaw stretching facial spasms or contortions, rapid and involuntary contortions of the tongue, stiffness in the extremities, lack of coordination, unsteady gait, excessive blinking of the eye lids, spasms involving the face, neck, and other parts of the body.

Also known as:

Extra-pyramidal reaction, Tardive dyskinesia from Phenothiazines, Drug-Induced Dyskinesia, Dystonia, Dyskinesia, phenothiazine induced extra-pyramidal reaction, Drug induced acute dystonia, Drug Induced Dystonia, Blepharospasm

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.