Drug-Induced Cardiomyopathy Research Dashboard
Double-blind human trials
Clinical human trials
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CannaKeys has 6 studies associated with Drug-Induced Cardiomyopathy.
Here is a small sampling of Drug-Induced Cardiomyopathy studies by title:
- Reverse Takotsubo Cardiomyopathy Precipitated by Chronic Cocaine and Cannabis Use
- Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis.
- Pharmacological Inhibition of CB1 Cannabinoid Receptor Protects Against Doxorubicin-Induced Cardiotoxicity
Components of the Drug-Induced Cardiomyopathy Research Dashboard
- Dosing information available for Drug-Induced Cardiomyopathy
- Chemotype guidance for treating Drug-Induced Cardiomyopathy with cannabis
- Synopsis of cannabis research for Drug-Induced Cardiomyopathy
- Individual study details for Drug-Induced Cardiomyopathy
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Overview - Drug-Induced Cardiomyopathy
Description of Drug-Induced Cardiomyopathy
A number of chemotherapy drugs are limited in their usage due to their cardio-toxic effects. Chemotherapy induced cardiotoxicity is responsible for one of the most significant adverse effects significantly contributing to overall loss of quality of life and mortality. It can lead to myocardial dysfunction, heart failure and death.
Certain Infectious and Parasitic Diseases
ICD-10 Code: I42.7
Drug-Induced Cardiomyopathy Symptoms:
Chest pain, shortness of breath, build-up of fluids, health failure
Also known as:
Cardiac Toxicity, Cardiomyopathy due to drug, Toxic cardiomyopathy
THC Interaction with Pharmaceutical Drugs
- THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example.
- THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin). Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
- Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
CBD Interaction with Pharmaceutical Drugs
- CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
- Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.