Digestive System – Cannabis and Cannabinoid Research

Digestive System Research Dashboard


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CannaKeys has 1481 studies associated with Digestive System.

Here is a small sampling of Digestive System studies by title:

Components of the Digestive System Research Dashboard

  • Medical conditions associated with Digestive System
  • Synopsis of cannabis research for Digestive System
  • Chemotype guidance for Digestive System
  • Individual study details for Digestive System

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Overview - Digestive System

Description of Digestive System

The digestive system is responsible for the digestion, absorption, and elimination of food and drink and psychic (mental/emotional) materials. It begins at the mouth (saliva, chewing), goes down throat and esophagus, enters the stomach, (it passes the liver, gall-bladder and pancreas), enters the small intestines, moves into the large intestines (ascending, transverse, descending, sigmoid, rectum), and ending with the anus. Additionally, the digestive tract is home to the microbiome (a vast colony of micro-organisms). A healthy microbiome positively affects mood (e.g. the feel good molecule serotonin is primarily made in the gut), energy production, and immune responses for instance. In contrast, when unhealthy (pathological) microbes take over we lose resilience and become vulnerable to disease.  

Digestive System and ECS-Based Interactions

The ECS (receptor sites, cannabinoids, degrading enzymes, and related compounds) are widely distributed throughout the gut (including the enteric immune system) with regional differences and organ-specific actions. The ECS, either in part or significantly, modulates taste, appetite or satiation and be extension weight (via CB1), produce gut-protection (i.e. without effective gut barrier bacterial-based lipopolysaccharide (LPI) seep into the blood causing chronic low-grade inflammation-a causative factor atherosclerosis for example), digestion (e.g. gastric secretion, energy balance/metabolism), the movement of chime (gut motility), and the modulation of nausea and vomiting for example. The ECS may also support a healthy microbiome which in turn improves mood and immune function, assist in neutralizing toxins, and helps to synthesize vitamins (e.g. K and certain B’s). Dysfunction of the ECS (e.g. poor ECS-tone, ECS-deficiency) may play a significant role in chronic gut (e.g. IBS, Crohn’s disease) and mood disorders (e.g. depression, anxiety).

Digestive System Medical Specialists

Gastrologist, Gastroenterologist, Enterologist, Proctologist

Also Known As:

Gastrointestinal  System, Excretory System, Alimentary Canal

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.