To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
Here is a small sampling of Diabetes Mellitus studies by title:
Ready to become a subscriber? Go to our PRICING page.
Traditionally, orthodox medicine categorizes diabetes into Type I, Type II, and gestational diabetes. The terminology has changed, and these are now considered subtypes of the umbrella category of metabolic disease called diabetes mellitus or DM.
Type I diabetes was once called juvenile diabetes because it mainly occurs in children or adolescents. In T1DM, the pancreas stops producing the hormone insulin due to the autoimmune destruction of the beta cells. Without insulin, the body cannot use the food life depends on, cellular sugar. Therefore, treatment consists of daily insulin injections, usually self-administered by patients.
Type II diabetes, formerly called adult-onset diabetes, is the most common form. In T2DM, the body's cells are insensitive to the presence of insulin and ignore it. This causes the pancreas to begin overproduction of insulin, lose cells as it tires out, and eventually not produce enough insulin. This prevents the body from converting sugar into energy. Early T2DM usually does not require the use of insulin; modern medical practitioners generally prescribe lifestyle interventions and patient education first and offer oral pharmaceuticals.
Advanced diabetes, primarily Type I or Type II, is potentially life-threatening if uncontrolled. Complications diminish one's life expectancy and quality of life. Providers should focus on DM prevention, routine screening, and management since DM often presents asymptomatically.
Gestational diabetes (diabetes that occurs during some pregnancies) most often self-corrects after delivery. While poorly understood, it is hypothesized that hormonal changes during pregnancy may produce temporary insulin resistance, producing higher-than-normal blood sugar levels.
There are several other endocrinopathies and genetic disorders (A. Sapra et al., 2023) that are associated with or predispose patients to DM, such as MODY, acromegaly, Cushing syndrome, glucagonoma, hyperthyroidism, hyperaldosteronism, and somatostatinoma.
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.