Crohn’s Disease – Cannabis THC : CBD Ratios

Crohn's Disease Research Dashboard

12

Primary Studies

24

Related Studies

36

Total Studies

Clinical Studies

2

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

9

Meta-analyses/Reviews

0

Animal studies

1

Laboratory studies

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CannaKeys has 36 studies associated with Crohn's Disease.

Here is a small sampling of Crohn's Disease studies by title:


Components of the Crohn's Disease Research Dashboard

  • Dosing information available for Crohn's Disease
  • Chemotype guidance for treating Crohn's Disease with cannabis
  • Synopsis of cannabis research for Crohn's Disease
  • Individual study details for Crohn's Disease

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Overview - Crohn's Disease

Description of Crohn's Disease

Crohn's disease is a chronic inflammatory condition that, unlike other types of inflammatory bowel diseases (IBD), which typically centers on the mucosal membrane of the large colon, can affects any part of the digestive tract (from mount to the anus) and can also reach deeper into the tissues of the gut (most commonly in the small intestines and colon). Its exact cause is still subject to ongoing investigation but it is considered to be an autoimmune disorder. Causes may include a chronic and overly reactive immune system response, environmental toxins, or microbial pathogens for example. There is no cure within orthodox medicine for Crohn's disease and treatment usually includes drugs that suppress the immune system (e.g. steroids) and surgery.

Disease Classification

Condition: Crohn's Disease
Disease Family: Intestinal Disorder
Organ System: Digestive System
ICD-10 Chapter: Diseases of the Digestive System
ICD-10 Code: K50

Crohn's Disease Symptoms:

Diarrhea (frequent bowel movements), weakness, abdominal discomfort (e.g. pain, cramping, bloating, flatulence), bloody stool, loss of appetite, may also have signs of chronic inflammation (e.g. skin, joints), mouth sores, ulcer formation

Also known as:

Crohn's, Regonal Enteritis, Terminal Ileitis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.