Chemotherapy-induced Nausea & Vomiting (CINV) – Cannabis Research

Chemotherapy-induced Nausea & Vomiting (CINV) Research Dashboard

43

Primary Studies

18

Related Studies

61

Total Studies

Clinical Studies

0

Clinical Meta-analyses

19

Double-blind human trials

5

Clinical human trials

Pre-Clinical Studies

17

Meta-analyses/Reviews

2

Animal studies

0

Laboratory studies

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CannaKeys has 61 studies associated with Chemotherapy-induced Nausea & Vomiting (CINV).

Here is a small sampling of Chemotherapy-induced Nausea & Vomiting (CINV) studies by title:


Components of the Chemotherapy-induced Nausea & Vomiting (CINV) Research Dashboard

  • Dosing information available for Chemotherapy-induced Nausea & Vomiting (CINV)
  • Chemotype guidance for treating Chemotherapy-induced Nausea & Vomiting (CINV) with cannabis
  • Synopsis of cannabis research for Chemotherapy-induced Nausea & Vomiting (CINV)
  • Individual study details for Chemotherapy-induced Nausea & Vomiting (CINV)

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Overview - Chemotherapy-induced Nausea & Vomiting (CINV)

Description of Chemotherapy-induced Nausea & Vomiting (CINV)

Nausea is an uneasy sensation in the stomach area with the expectancy or urge to vomit. Nausea and vomiting are sign or symptoms not a disease in and by itself. Instead they are associated with a variety of underlying pathologies such as severe migranes, morning sickness during pregnancy, infections, presence of toxins, motion (e.g., car, boat) sickness, food poisoning, immuno- or chemotherapeutic agents, and many other pharmaceutical drugs for instance.

Disease Classification

Condition: Chemotherapy-induced Nausea & Vomiting
Disease Family:
Organ System: Digestive System
ICD-10 Chapter: Injury, poisoning and certain other consequences of external causes
ICD-10 Code: T45.1X5A

Chemotherapy-induced Nausea & Vomiting (CINV) Symptoms:

Nausea, vomiting, loss of appetite, weightloss, dehydration, electrilyte imbalances, dizzyness, loss of consciousness (fainting), anxiety

Also known as:

Drug-induced nausea & vomiting, drug-induced hyperemesis, drug-induced emesis, acute nausea and vomiting, chronic nausea and vomiting, anticipatory nausea and vomiting, refractory nausea and vomiting, drug poisoning, side-effect of antineoplastic drug, adverse effect of antineoplastic drug, antineoplastic adverse reaction, poisoning and toxic effects of drugs, breakthrough nausea and vomiting, intractable nausea and vomiting, throwing up after taking drugs

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.