Cannabis Use Disorder Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 906 studies associated with Cannabis Use Disorder.
Here is a small sampling of Cannabis Use Disorder studies by title:
- Enhancing Interpretable, Transparent, and Unobtrusive Detection of Acute Marijuana Intoxication in Natural Environments: Harnessing Smart Devices and Explainable AI to Empower Just-In-Time Adaptive Interventions: Longitudinal Observational Study
- Vortioxetine improves illness severity for cannabis users with anxiety and depressive symptoms in a 6-month randomized controlled study
- Regenerative surgical therapy in a frequent cannabis consumer: A case study
- The role of myocardial bridge of the left anterior descending artery in a sudden death of a ketamine and cannabis user. Addressing the uncertainties on the cause of death in a forensic pathologist's casework
- The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies
Components of the Cannabis Use Disorder Research Dashboard
- Dosing information available for Cannabis Use Disorder
- Chemotype guidance for treating Cannabis Use Disorder with cannabis
- Synopsis of cannabis research for Cannabis Use Disorder
- Individual study details for Cannabis Use Disorder
Ready to become a subscriber? Go to our PRICING page.
Cannabis Use Disorder Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 906 studies associated with Cannabis Use Disorder.
Here is a small sampling of Cannabis Use Disorder studies by title:
- Enhancing Interpretable, Transparent, and Unobtrusive Detection of Acute Marijuana Intoxication in Natural Environments: Harnessing Smart Devices and Explainable AI to Empower Just-In-Time Adaptive Interventions: Longitudinal Observational Study
- Vortioxetine improves illness severity for cannabis users with anxiety and depressive symptoms in a 6-month randomized controlled study
- Regenerative surgical therapy in a frequent cannabis consumer: A case study
- The role of myocardial bridge of the left anterior descending artery in a sudden death of a ketamine and cannabis user. Addressing the uncertainties on the cause of death in a forensic pathologist's casework
- The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies
Components of the Cannabis Use Disorder Research Dashboard
- Dosing information available for Cannabis Use Disorder
- Chemotype guidance for treating Cannabis Use Disorder with cannabis
- Synopsis of cannabis research for Cannabis Use Disorder
- Individual study details for Cannabis Use Disorder
Ready to become a subscriber? Go to our PRICING page.
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Overview - Cannabis Use Disorder
Description of Cannabis Use Disorder
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition 2013 (DSM-V) now recognizes the diagnosis of Cannabis Use Disorder (CUD). While the majority of cannabis withdrawal symptoms are psychological, the DSM-V also includes possible physical symptoms, one or more of (see list below), which may begin 24-48 hours after a person stops using cannabis after prolonged (few months) and heavy use:
- Headache
- Abdominal pain
- Sweating
- Fever
- Chills,
- Shakiness
The DSM-V does not mention that cannabis addiction is associated primarily with its primary psychoactive constituent, i.e., THC, nor does it say that other phytocannabinoids, such as CBD, may have therapeutic properties to counter the potentially addictive effect of THC.
Adolescents appear to be most prone to these addictive effects. Research shows patients who initiate cannabis use before age 16 have an increased risk of developing CUD (Connor et al., 2021). Starting before age 18 is associated with numerous long-term detriments, including increased risk of car accidents, antisocial behavior, polysubstance use, and early school dropout.
Of important note to healthcare providers, a 2024 study (N. G. Choi et al., 2024) reports that CUD is associated with moderate to severe mental illness in 38.4% of patients, and 52.4% had other substance use disorders. This does not imply a cause-effect relationship, but it emphasizes how important it is to work on non-pharmacologic therapies like developing coping skills, MET, or CBT with the help of a licensed psychologist or therapist. Adolescents may require advanced multidisciplinary support.
Accurate diagnosis of CUD and management, including comorbid mental health conditions, is paramount. There are currently no FDA-approved pharmacological treatments for CUD. However, CBD and nabiximols (1:1 THC: CBD) may help ease withdrawal symptoms despite not yet providing complete abstinence potential (M. Montebello et al., 2023; K. C. Winters et al., 2021).
Disease Classification
Condition: Addiction - CannabisDisease Family: Addiction
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F12.2
Cannabis Use Disorder Symptoms:
Craving, interference with social obligations, impaired control, development of tolerance, difficulty concentrating, restlessness, depression, sleep disturbances, withdrawal (irritability, anger, nervousness, anxiety, insomnia, lack of appetite, dysphoria, shakiness, weight loss, depressed mood, abdominal pain, sweating, chills, fever, headache), increasing priority resulting in social and physical risk, and psychological dependence.Also known as:
Cannabis Addiction, Cannabis Dependence, Addiction to Cannabis, CUDDrug Interactions
THC Interaction with Pharmaceutical Drugs
- Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol.
- THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
- Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
CBD Interaction with Pharmaceutical Drugs
- Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
- Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.
If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
THC/CBD Interaction with Pharmaceutical Drugs
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
