Breast Cancer Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 124 studies associated with Breast Cancer.
Here is a small sampling of Breast Cancer studies by title:
- Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies
- CBD-oil as a potential solution in case of severe tamoxifen-related side effects
- Phytocannabinoids in Triple Negative Breast Cancer Treatment: Current Knowledge and Future Insights
- Δ9-Tetrahydrocannabinol stimulation of estrogen receptor-positive MCF-7 breast cancer cell migration: Interfering interaction with the estrogenic milieu
- A Coala-T-Cannabis Survey Study of breast cancer patients' use of cannabis before, during, and after treatment
Components of the Breast Cancer Research Dashboard
- Dosing information available for Breast Cancer
- Chemotype guidance for treating Breast Cancer with cannabis
- Synopsis of cannabis research for Breast Cancer
- Individual study details for Breast Cancer
Ready to become a subscriber? Go to our PRICING page.
Breast Cancer Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 124 studies associated with Breast Cancer.
Here is a small sampling of Breast Cancer studies by title:
- Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies
- CBD-oil as a potential solution in case of severe tamoxifen-related side effects
- Phytocannabinoids in Triple Negative Breast Cancer Treatment: Current Knowledge and Future Insights
- Δ9-Tetrahydrocannabinol stimulation of estrogen receptor-positive MCF-7 breast cancer cell migration: Interfering interaction with the estrogenic milieu
- A Coala-T-Cannabis Survey Study of breast cancer patients' use of cannabis before, during, and after treatment
Components of the Breast Cancer Research Dashboard
- Dosing information available for Breast Cancer
- Chemotype guidance for treating Breast Cancer with cannabis
- Synopsis of cannabis research for Breast Cancer
- Individual study details for Breast Cancer
Ready to become a subscriber? Go to our PRICING page.
Select New Condition
Overview - Breast Cancer
Description of Breast Cancer
As the most common type of cancer diagnosed in women, breast cancer accounts for over 1 in 10 new cancer diagnoses yearly. In the United States, invasive breast cancer will affect 1 in 8 women.
Unfortunately, it is also the second most common cause of cancer death among women worldwide. Most of the time, it develops silently and is only discovered upon routine screening. The risk factors for breast cancer include older age, biological female gender, histologic factors, personal and family history of breast cancer, reproductive risk factors, excessive alcohol consumption, environmental exposures, and exogenous hormone use.
Breast cancer most commonly originates in the milk ducts from corrupted DNA in breast cell(s), which, left unchecked, can invade the basement membrane and surrounding breast tissue with devastating results. While often benign in origin, a dreaded lump in the breast can develop into a cancerous growth if not detected early.
Chronically swollen lymph nodes around the breast or in the armpit may be signs of cancer. Other symptoms include single nipple discharge, pain in the area, inverted nipple, discoloration, heat, redness, swelling of the affected tissue, or a change in breast tissue texture.
Orthodox treatment usually involves surgery, pharmaceuticals (chemotherapy or hormonal therapy), or radiation that may have significant complications and side effects. Many breast cancer patients report using complementary cannabinoid-based therapies for managing both primary cancer symptoms and chemo side effects like pain, nausea, anxiety, sleep, appetite, improving quality of life, and more.
Medical therapies for breast cancer have evolved over the past four decades, and the prognosis of early breast cancer is improving. Stage 0 and Stage I breast cancer have a 100% 5-year survival rate. Stage II and III breast cancer have five-year survival rates of 93% and 72%, respectively. However, once breast cancer is systemically spread (Stage IV), the prognosis drops to a 5-year survival rate of 22%. This emphasizes the importance of screening in the primary care setting.
Disease Classification
Condition: Cancer - BreastDisease Family: Cancer
Organ System: Reproductive System
ICD-10 Chapter: Neoplasms
ICD-10 Code: C50
Breast Cancer Symptoms:
Lump in the breast, pain, inverted nipple (or other changes to the breast/areola/nipple), swelling, redness, irritation, peeling, ulceration, flaking of the skin, unusual nipple discharge, axillary lymphadenopathy, and any obvious metastasesAlso known as:
Malignant neoplasm of the breast, group 1 (luminal A), group 2 (luminal B), group 3 (HER2-positive), and group 4 include tumors that are triple-negative (and also include ER negative, PR negative, and HER2 negative), Secondary malignant neoplasm of breast, Lobular carcinoma in situ of breast, LCIS, Cancer metastatic to breast, Intraductal carcinoma in situ of breast, ductal carcinoma in situ, ductal carcinoma in situ of breast, DCIS, cancer of the breast, Primary malignant neoplasm of breast, Primary malignant neoplasm of male breast, male breast cancer, mammary dysplasia of breast, mammary tumor, mammary cancer, in situ neoplasm of breast, carcinoma in situ of breast, breast carcinoma, breast carcinoma in situ, breast neoplasm, metastatic breast cancer, Ductal hyperplasiaDrug Interactions
THC Interaction with Pharmaceutical Drugs
- Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol.
- THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
- Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
CBD Interaction with Pharmaceutical Drugs
- Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
- Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.
If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
THC/CBD Interaction with Pharmaceutical Drugs
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
