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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
Here is a small sampling of Brachial Plexus Disorders studies by title:
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This condition results from trauma to the brachial plexus, a cluster of nerves connecting the spinal cord from the lower cervical to the upper thoracic vertebrae to the hand, arm, chest, and shoulder. Technically speaking, the ventral rami of the C5 through T1 spinal nerves form the roots of the brachial plexus. Proximal to this convergence of the spinal nerves, there are dorsal root ganglia.
Avulsion refers to a tear-like injury and may be either pre- or postganglionic. Brachial plexus injury (BPI) is a significantly painful and functionally impairing injury that can take years to heal. Preganglionic BPIs have a worse prognosis and require early surgical intervention.
BPI is usually accompanied by severe pains that don't tend to respond very well to opioids, anticonvulsants, and tricyclic antidepressants frequently used to treat this type of central neuropathic pain syndrome.
Brachial plexus injury may also lead to Horner syndrome if the roots of C8 - T1 are affected, causing the pathognomonic triad of miosis, ptosis, and anhidrosis. In addition, root avulsions may cause rhomboid/paraspinal muscle paralysis, medial scapular winging, and hemidiaphragmatic paralysis.
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.