Autism and Pervasive Developmental Disorders Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 113 studies associated with Autism and Pervasive Developmental Disorders.
Here is a small sampling of Autism and Pervasive Developmental Disorders studies by title:
- Cannabinoid treatment for the symptoms of autism spectrum disorder
- Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program
- Clinical and Family Implications of Cannabidiol (CBD)-Dominant Full-Spectrum Phytocannabinoid Extract in Children and Adolescents with Moderate to Severe Non-Syndromic Autism Spectrum Disorder (ASD): An Observational Study on Neurobehavioral Management
- Cannabinoids as alleviating treatment for core symptoms of autism spectrum disorder in children and adolescents: a systematic review
- Prenatal cannabis use and the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring: A systematic review and meta-analysis
Components of the Autism and Pervasive Developmental Disorders Research Dashboard
- Dosing information available for Autism and Pervasive Developmental Disorders
- Chemotype guidance for treating Autism and Pervasive Developmental Disorders with cannabis
- Synopsis of cannabis research for Autism and Pervasive Developmental Disorders
- Individual study details for Autism and Pervasive Developmental Disorders
Ready to become a subscriber? Go to our PRICING page.
Autism and Pervasive Developmental Disorders Research Dashboard
What am I missing as a non-subscriber?
To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 113 studies associated with Autism and Pervasive Developmental Disorders.
Here is a small sampling of Autism and Pervasive Developmental Disorders studies by title:
- Cannabinoid treatment for the symptoms of autism spectrum disorder
- Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program
- Clinical and Family Implications of Cannabidiol (CBD)-Dominant Full-Spectrum Phytocannabinoid Extract in Children and Adolescents with Moderate to Severe Non-Syndromic Autism Spectrum Disorder (ASD): An Observational Study on Neurobehavioral Management
- Cannabinoids as alleviating treatment for core symptoms of autism spectrum disorder in children and adolescents: a systematic review
- Prenatal cannabis use and the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring: A systematic review and meta-analysis
Components of the Autism and Pervasive Developmental Disorders Research Dashboard
- Dosing information available for Autism and Pervasive Developmental Disorders
- Chemotype guidance for treating Autism and Pervasive Developmental Disorders with cannabis
- Synopsis of cannabis research for Autism and Pervasive Developmental Disorders
- Individual study details for Autism and Pervasive Developmental Disorders
Ready to become a subscriber? Go to our PRICING page.
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Overview - Autism and Pervasive Developmental Disorders
Description of Autism and Pervasive Developmental Disorders
Thirty years ago, few people had ever heard the word autism. Circa 1975, only one in 5,000 children was diagnosed with this condition. Nowadays, it is a household word, and almost everybody knows of someone suffering from the disease.
The allopathic community considers autism a neurodevelopmental disorder that begins early in childhood. Government statistics suggest that the prevalence rate of autism is increasing by 10-17% annually, doubling roughly every five years since 1980.
The pervasiveness of autism seems to be growing exponentially. However, the uptick is also partly because clinicians are better trained at diagnosing autism and intervening earlier than before.
Pharmaceutical medications such as Ritalin, an amphetamine-like drug, are given to millions of children annually to control symptoms. This happens even though there are no FDA-approved treatments for the core symptoms of ASD.
Now, there is new hope in cannabinoids like CBD. However, pregnant individuals should avoid cannabis exposure to prevent significantly increasing fetal risk of developing ASD or ADHD.
Disease Classification
Condition: AutismDisease Family: Mental Disorders
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F84
Autism and Pervasive Developmental Disorders Symptoms:
Symptoms of autism fall on a spectrum range between the following: the autism savant, atypical social interaction, atypical communicating, atypical interests, compulsive behavior, and destructive behavior.Also known as:
ASD, Infantile Autism, Childhood-onset autism, autistic disorder, autism disorder, autism spectrum disorder, infantile autism, Asperger's Syndrome, pervasive developmental disorder, developmental disorder, autistic disorder of childhood onset, Kanner syndrome, Kanner's syndrome, low functioning autism, high functioning autism, autism with speech disturbances or language delay, residual state autism disorder, SYNGAP1-related intellectual disability, SYNGAP1, specific developmental disorders of speech and language.Drug Interactions
THC Interaction with Pharmaceutical Drugs
- Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol.
- THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
- Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.
If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
CBD Interaction with Pharmaceutical Drugs
- Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects.
- Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
- Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.
If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
THC/CBD Interaction with Pharmaceutical Drugs
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Dosing Considerations
THC Dosage Considerations
- THC micro dose: 0.1 mg to 0.4 mg
- THC low dose: 0.5 mg to 5 mg
- THC medium dose: 6 mg to 20 mg
- THC high dose: 21 mg to 50+ mg
CBD Dosage Considerations
- CBD low dose: 0.4 mg to 19 mg
- CBD medium dose: 20 mg to 99 mg
- CBD high dose: 100 mg to 800+ mg (upper limits tested ~1,500mg)
Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You
should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a
medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
