Amyloidosis and Familial Mediterranean Fever – Cannabis Research

Amyloidosis and Familial Mediterranean Fever Research Dashboard


Primary Studies


Related Studies


Total Studies

Clinical Studies


Clinical Meta-analyses


Double-blind human trials


Clinical human trials

Pre-Clinical Studies




Animal studies


Laboratory studies

What am I missing as a non-subscriber?

To see a full dashboard with study details and filtering, go to our DEMO page.

As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.

CannaKeys has 4 studies associated with Amyloidosis and Familial Mediterranean Fever.

Here is a small sampling of Amyloidosis and Familial Mediterranean Fever studies by title:

Components of the Amyloidosis and Familial Mediterranean Fever Research Dashboard

  • Dosing information available for Amyloidosis and Familial Mediterranean Fever
  • Chemotype guidance for treating Amyloidosis and Familial Mediterranean Fever with cannabis
  • Synopsis of cannabis research for Amyloidosis and Familial Mediterranean Fever
  • Individual study details for Amyloidosis and Familial Mediterranean Fever

Ready to become a subscriber? Go to our PRICING page.

Select New Condition

Search By Keyword

Filter Condition

Members can filter by the following criteria:

  • Study Type
  • Chemotype
  • Cannabinoids & Endocannabinoids
  • Terpenes
  • Receptors
  • Ligands
  • Study Result
  • Year of Publication

Overview - Amyloidosis and Familial Mediterranean Fever

Description of Amyloidosis and Familial Mediterranean Fever

Amyloidosis is an umbrella term that describes a number of similar conditions in which abnormal proteins build up in parts of the human body. Some types of amyloidosis are related to co-occurring diseases.

For example, in Familial Mediterranean Fever, a mutation in the gene that produces the amino acid pyrin causes episodic and overly-reactive inflammatory responses most commonly in the abdomen, chest and the joints. The condition is characterized by irregular but recurring flare-ups. The associated pain and fevers are commonly treated with analgesia and NSAIDs. Patients are usually asymptomatic between flare-ups.

Disease Classification

Condition: Fam. Mediterranean Fever
Disease Family: Inflammatory Disease (Hereditary)
Organ System: Digestive System
ICD-10 Chapter: Endocrine, Nutritional and Metabolic Diseases
ICD-10 Code: E85

Amyloidosis and Familial Mediterranean Fever Symptoms:

Fever; abdominal pain (can be severe); inflammation; painful, swollen joints, ankles, or legs; rash around the ankles; pleural pain; occasional testicular swelling; high white blood cell count; fatigue and weakness; shortness of breath; numbness, tingling, or pain in the hands or feet; diarrhea, possibly with blood, or constipation; tongue enlargement and changes; and skin changes such as thickening, easy bruising, and purplish discoloration around the eyes.

Also known as:

FMF, Amyloidosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.