Testicular Cancer – Cannabis THC : CBD Ratios

Testicular Cancer Research Dashboard

4

Primary Studies

1

Related Studies

5

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 5 studies associated with Testicular Cancer .

Here is a small sampling of Testicular Cancer studies by title:


Components of the Testicular Cancer Research Dashboard

  • Dosing information available for Testicular Cancer
  • Chemotype guidance for treating Testicular Cancer with cannabis
  • Synopsis of cannabis research for Testicular Cancer
  • Individual study details for Testicular Cancer

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Overview - Testicular Cancer

Description of Testicular Cancer

Testicular cancer formation begins in the testes inside the scrotum a loose and flexible bag of tissue underneath the penis. There are three unorthodox observations that can be made about testicular cancer. One, it is relatively rare two, it is the most common type of cancer affecting young males between the age of 15-35, and three it tends to responds well to orthodox treatments methodologies. Physiologically testicular cancer originates in germ cells (cells that produce sperm). There are two types, seminoma and non-seminoma. The difference is typically characterized by age of occurrence and aggressiveness. Non-seminoma testicular cancer tends to develop at a younger age and grow and spread more rapidly than the seminoma type.

Disease Classification

Condition: Testicular Cancer
Disease Family:
Organ System: Reproductive System
ICD-10 Chapter: Malignant neoplasm of testis
ICD-10 Code: C62

Testicular Cancer Symptoms:

Chronic presence of aches or pains in testis (may radiate to groin), lumps or swelling in or around the testis (usually one-sided), hormonal changes leading to enlarged breasts.

Also known as:

Malignant neoplasm of testis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.