Sunburn – Cannabis THC : CBD Ratios

Sunburn Research Dashboard

3

Primary Studies

2

Related Studies

5

Total Studies

Clinical Studies

1

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

0

Animal studies

2

Laboratory studies

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CannaKeys has 5 studies associated with Sunburn.

Here is a small sampling of Sunburn studies by title:


Components of the Sunburn Research Dashboard

  • Dosing information available for Sunburn
  • Chemotype guidance for treating Sunburn with cannabis
  • Synopsis of cannabis research for Sunburn
  • Individual study details for Sunburn

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Overview - Sunburn

Description of Sunburn

Sunburn is an injury caused by an overexposure to solar radiation (i.e. UV-light). While smaller amounts of sunlight are important for our health and well-being (i.e. the body converts cholesterol into vitamin D utilizing sunlight) excessive exposure can produce varying degrees of burns. Melanin a natural pigment found in the skin that is activated by UV light and via a process called melanogenesis turns the skin darker to better protect the body from radiation damage. The darker the skin the more melanin the better the protection. The process by which melanin forms, that is melanogenesis plays a critical role in the protection of the skin against ultraviolet irradiation.

Disease Classification

Condition: Sunburn
Disease Family:
Organ System: Integumentary System
ICD-10 Chapter: Diseases of the skin and subcutaneous tissue
ICD-10 Code: L55

Sunburn Symptoms:

Depending on exposure minor symptoms include tenderness, pain, reddening of the skin (later peeling, rash formation), moderate exposure can produces additional blister formations and more severe pains (including nausea, vomiting, reduced immunity), while severe cases can be fatal. Long-term skin damage may include wrinkles, rough skin, damage to the eyes, macules (brown spots), and mutations potentially leading to the genesis of various forms of skin cancer.

Also known as:

Sun Exposure

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.