Suicide Attempt – Cannabis Research

Suicide Attempt Research Dashboard

31

Primary Studies

24

Related Studies

55

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind Clinical Trials

2

Clinical Trials

Pre-Clinical Studies

29

Meta-analyses/Reviews

0

Animal Studies

0

Laboratory Studies

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CannaKeys has 55 studies associated with Suicide Attempt.

Here is a small sampling of Suicide Attempt studies by title:


Components of the Suicide Attempt Research Dashboard

  • Dosing information available for Suicide Attempt
  • Chemotype guidance for treating Suicide Attempt with cannabis
  • Synopsis of cannabis research for Suicide Attempt
  • Individual study details for Suicide Attempt

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Overview - Suicide Attempt

Description of Suicide Attempt

While there are a great number of very specific and personal stories (individual motivations) for committing suicide there are also social factors that almost always apply and which were first posited by Émile Durkheim a French sociologist who published the now classical text (Le Suicide)1in 1897 that is still informing today’s students of sociology, psychology, and psychiatry alike. In it he argues that suicides have social and not just psychological causes and that a degree of social disconnection and lack of social belonging is in direct relationship to the degree of suicidal motivations. In other words, groups of people whether organized in families, tribes, by religion, organization, or societal institution in large that are successful in integrating individuals, by providing a sense of belonging and meaningful relationships have a significantly lower rate of self-harming behavior such as suicide. With that in mind consider this: of those veterans in the U.S. who were laid to rest in the years from 2001-2007 roughly one in five committed suicide (deployed 21.3%, non-deployed 19.7%). Within the orthodox consensus the connection between suicidal ideation or behavior is primarily associated with conditions such as anxiety or depression for example and treated accordingly with psycho-pharmaceuticals. Little attention is paid to societal conditions or their mental-emotional impact.

Disease Classification

Condition: Suicide Attempt
Disease Family:
Organ System: Mental/Emotional System
ICD-10 Chapter: Injury, Poisoning and Certain Other Consequences of External Causes
ICD-10 Code: T14.91

Suicide Attempt Symptoms:

Moodswings, an underlying mental condition such as anxiety (PTSD), depression, psychosis for example; expressions of hopelessness, planning or getting the means to commit suicide, expressing the wish to commit suicide, alienation, lack of meaningfull connections, desire to punish other with self-harm

Also known as:

Attempted Suicide

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • Tetrahydrocannabinol (THC) can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol. 
  • THC is metabolized by an inhibitor of several enzymatic liver pathways referred to as cytochrome P450 (aka CYP450). There are more than 50 enzymes belonging to this enzyme family, several of which are responsible for the breakdown of common drugs such as antidepressants (e.g., amitriptyline, doxepin, fluvoxamine), antipsychotics (haloperidol, clozapine, Stelazine), beta-blockers (e.g., propranolol), bronchodilators (e.g., theophylline), or blood thinners (e.g., warfarin). Thus, patients taking these medication classes may find that THC increases the concentration and effects of these drugs and the impact duration.
  • Clinical observation (not yet confirmed by clinical trials) suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

If you are interested in the interaction potential of specific pharmaceuticals with THC, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.

CBD Interaction with Pharmaceutical Drugs

  • Cannabidiol (CBD) may alter the action of metabolic enzymes (specific drug-transport mechanisms) and alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include anti-epileptics, psychiatric drugs, and drugs affecting metabolic enzymes.
  • Clinical observations (not yet confirmed by clinical trials) suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD.

If you are interested in the interaction potential of specific pharmaceuticals with CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.

THC/CBD Interaction with Pharmaceutical Drugs

In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.

If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.

Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).

However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)
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Disclaimer
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.