Stress and Life Management Difficulty – Cannabis THC : CBD Ratios

Stress and Life Management Difficulty Research Dashboard

60

Primary Studies

25

Related Studies

85

Total Studies

Clinical Studies

6

Double-blind human trials

8

Clinical human trials

Pre-Clinical Studies

15

Meta-analyses/Reviews

30

Animal studies

0

Laboratory studies

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CannaKeys has 85 studies associated with Stress and Life Management Difficulty.

Here is a small sampling of Stress and Life Management Difficulty studies by title:


Components of the Stress and Life Management Difficulty Research Dashboard

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  • Chemotype guidance for treating Stress and Life Management Difficulty with cannabis
  • Synopsis of cannabis research for Stress and Life Management Difficulty
  • Individual study details for Stress and Life Management Difficulty

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Overview - Stress and Life Management Difficulty

Description of Stress and Life Management Difficulty

A natural stress response is a complex physical, mental, and emotional cascade of events that rapidly occurs due to a very real or even just perceived threat (stressor) to our health and well-being. Body and mind will respond rapidly to assure survival and to return to balance (homeostasis). For instance, acute fear can tell you to step away from that cliff and in that sense is a great motivator that has your body's survival in mind. However, with chronic fears that just won't go away, stress molecules such as adrenalin and cortisol are produced on a continuous basis and in higher amounts, which in turn can have numerous real and serious ill-effects such as making the body more vulnerable to infections and increasing your risk of developing a host of potentially life-threatening diseases including heart disease and hypertension.

Disease Classification

Condition: Stress
Disease Family: Health and Well Being
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: Z73

Stress and Life Management Difficulty Symptoms:

Stress affects the body (e.g. free radicals, vulnerability to inflammation, muscular tension, co-morbidity with other conditions such as hypertension, heart disease, cancer), mind/emotion (e.g. anxiety, chronic worry, irritability, agression, sleep disturbances), and behavior (e.g. overeating, nicotene, alcohol, or drug use)

Also known as:

Burn-out, Lack of relaxation and leisure, Social role conflict

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.