Stimulant Dependence and Psychosis – Cannabis THC : CBD Ratios

Stimulant Dependence and Psychosis Research Dashboard

11

Primary Studies

5

Related Studies

16

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

7

Animal studies

0

Laboratory studies

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CannaKeys has 16 studies associated with Stimulant Dependence and Psychosis.

Here is a small sampling of Stimulant Dependence and Psychosis studies by title:


Components of the Stimulant Dependence and Psychosis Research Dashboard

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  • Chemotype guidance for treating Stimulant Dependence and Psychosis with cannabis
  • Synopsis of cannabis research for Stimulant Dependence and Psychosis
  • Individual study details for Stimulant Dependence and Psychosis

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Overview - Stimulant Dependence and Psychosis

Description of Stimulant Dependence and Psychosis

Methamphetamines are potent chemical stimulants of the central nervous system (CNS). Illegal meth-labs produce and dealer networks sell the drug under names such as crystal meth, ice, or speed for instance. It is a common recreational substance used to induce stimulating, euphoric, or aphrodisiac-related effects. A pharmaceutical version (e.g. adderall) is prescribed to patients with ADHA or as a weight-loss drug. While methamphetamines can produce near instant stimulation, focus and excitement they can also cause a number of unwanted effects including neurotoxicity, addiction or psychosis for example. Methamphetamine is most commonly taken by ingestion, inhalation, or injection. Common emotional realities produced by the substance range between happiness, excitement, alertness, and focus on the expansive side and on the constricting side may include irritability, anxiety, paranoia, strange and violent/aggressive behaviors for example. Additional physical adverse effects include addiction potential, lack of appetite, increases in heart, blood pressure, and respiratory rate (increase risk of heart attack and stroke), increase in body temperature, twitching, bad teeth for instance.

Disease Classification

Condition: Stimulant Dependence (Methamphetamine)
Disease Family: Addiction
Organ System: Mental/Emotional System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F15

Stimulant Dependence and Psychosis Symptoms:

Tachycardia, hypertension, moodswings (aggression to depression), psychosis, hallucinations (nightmarish), shaking (seizures), irregular heart rates, "crash and burn" as in extreme weakness and fatigue, hunger, craving for more stimulants (e.g. methamphetamine), photophobia

Also known as:

Methamphetamine addiction, Meth addiction, Methamphetamine toxicity

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.