Staph Infection – Cannabis THC : CBD Ratios

Staph Infection Research Dashboard

20

Primary Studies

2

Related Studies

22

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

2

Animal studies

17

Laboratory studies

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CannaKeys has 22 studies associated with Staph Infection.

Here is a small sampling of Staph Infection studies by title:


Components of the Staph Infection Research Dashboard

  • Dosing information available for Staph Infection
  • Chemotype guidance for treating Staph Infection with cannabis
  • Synopsis of cannabis research for Staph Infection
  • Individual study details for Staph Infection

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Overview - Staph Infection

Description of Staph Infection

Staph infections are an infection caused by the genus of bacteria called Staphylococcus. It is a mostly harmless and common member of the human microbiome (especially on the skin). However, when the barrier of the skin is compromised via cut or tears for example the bacteria can enter the body and cause infections. Certain strains of staphylococcus have developed a resistance to the usual antibiotic pharmaceuticals, which is the reason they are also referred to as superbugs or Multi-drug-Resistant Staphylococcus aureus (MRSA). People with weakened immune systems, chronic open wounds, surgical implants, and exposure to the bacteria are its most likely victims. The bacteria are spread via close skin-to-skin contact, contaminated items and surfaces, crowded living conditions, or poor hygiene.

Disease Classification

Condition: Staph Infection
Disease Family: Infectious Disease (Bacterium)
Organ System: Immune System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B95.6

Staph Infection Symptoms:

Infection to skin (e.g. boil), food-bourne infection of the gut, infection to mucus membranes (e.g. mouth sore, eye), infection of blood (incl. sepsis, bone, joints), infection of the pericardium, microbiome imbalances

Also known as:

MRSA, Methicillin-Resistant Staphylococcus Aureus, Golden Staph

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.