Rheumatoid Arthritis – Cannabis THC : CBD Ratios

Rheumatoid Arthritis Research Dashboard

22

Primary Studies

13

Related Studies

35

Total Studies

Clinical Studies

2

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

13

Meta-analyses/Reviews

2

Animal studies

5

Laboratory studies

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CannaKeys has 35 studies associated with Rheumatoid Arthritis.

Here is a small sampling of Rheumatoid Arthritis studies by title:


Components of the Rheumatoid Arthritis Research Dashboard

  • Dosing information available for Rheumatoid Arthritis
  • Chemotype guidance for treating Rheumatoid Arthritis with cannabis
  • Synopsis of cannabis research for Rheumatoid Arthritis
  • Individual study details for Rheumatoid Arthritis

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Overview - Rheumatoid Arthritis

Description of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is the most crippling form of arthritis, deforming joints and bending bodies. It is considered a systemic autoimmune disorder, which according to orthodox medicine occurs when something goes wrong with the body’s immune system and it attacks healthy parts of the body especially the synovium (i.e. the lining of the membranes that surround the joints). More specifically, RA is posited to an immune system mediated chronic inflammatory disease associated a complex underlying pathology involving a great number of specific tissues/cells types such as osteoclasts, fibroblast-like synoviocytes, T cells, B cells, and macrophages as well as various inflammatory cytokines such as interleukin-1β, interleukin-6, tumor necrosis factor-α, and chemokines for example. However, its precise causes are poorly understood and still subject to scientific inquiry.

Disease Classification

Condition: Rheumatoid Arthritis
Disease Family: Autoimmune Disorder
Organ System: Skeletal System
ICD-10 Chapter: Diseases of the Musculoskeletal System and Connective Tissue
ICD-10 Code: M05-M06

Rheumatoid Arthritis Symptoms:

Swollen joints (e.g. painful, feeling hot), generalized weakness, fever. RA can also progress to affect organs (e.g. heart, lung, skin)

Also known as:

RA, Felty's syndrome, seropositive rheumatoid arthritis, Adult-onset Still's disease, Rheumatoid bursitis, Rheumatoid nodule, Inflammatory polyarthropathy

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.