Ovarian Cancer – Cannabis THC : CBD Ratios

Ovarian Cancer Research Dashboard

6

Primary Studies

0

Related Studies

6

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

0

Animal studies

4

Laboratory studies

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CannaKeys has 6 studies associated with Ovarian Cancer.

Here is a small sampling of Ovarian Cancer studies by title:


Components of the Ovarian Cancer Research Dashboard

  • Dosing information available for Ovarian Cancer
  • Chemotype guidance for treating Ovarian Cancer with cannabis
  • Synopsis of cannabis research for Ovarian Cancer
  • Individual study details for Ovarian Cancer

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Overview - Ovarian Cancer

Description of Ovarian Cancer

Within orthodox medicine the causes for ovarian cancers are poorly understood but a number of potential risk factors have been described such as postmenopausal hormone replacement therapies, inherited mutations, family history, previous fertility treatments, exposure to environmental toxins (e.g. herbicides, pesticides) and obesity for example. According to the CDC ovarian cancer is the second most common gynecological cancer. It begins with mutated cells in the ovaries that grow and spread.

Disease Classification

Condition: Ovarian Cancer
Disease Family:
Organ System: Reproductive System
ICD-10 Chapter: Neoplasms
ICD-10 Code: C56

Ovarian Cancer Symptoms:

Pelvic discomfort/pain, abdominal swelling, feeling full quickly when eating, frequent desire to pee, changes in bowel movements (e.g. constipation), generalized weakness, unexplained weight loss, painful intercourse, back pain, changes in menses.

Also known as:

Ovarian cancer

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.