To see a full dashboard with study details and filtering, go to our DEMO page.
As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
Here is a small sampling of Nicotine Dependence and Withdrawal studies by title:
Ready to become a subscriber? Go to our PRICING page.
Nicotine in various forms (e.g., cigarettes, chews, pipe tobacco, vape pens, etc.) is made from the tobacco plant. Acute tobacco poisoning, or nicotine poisoning, is a serious health risk that can be lethal. Nicotine, the primary addictive substance in tobacco, is a toxic compound that can lead to severe symptoms and complications when ingested, inhaled, or absorbed through the skin in large amounts. Symptoms of acute tobacco poisoning can range from nausea, vomiting, and abdominal pain to seizures, respiratory failure, and cardiac arrest. Extreme cases can result in coma or death due to respiratory failure or cardiac arrest.
Nicotine addiction develops over time. Nicotine receptors in the brain release dopamine, triggering a pleasurable effect. However, with chronic use, the number of nicotine receptors increases and changes the receptive structure of the brain.
Nicotine addiction is a severe public health issue due to its harmful effects on the human body. Prolonged nicotine use can lead to severe health complications like heart disease, stroke, and lung cancer. It can also cause damage to the respiratory and circulatory systems, leading to chronic bronchitis, COPD, emphysema, and peripheral artery disease.
Besides physical health problems, nicotine addiction and withdrawal can induce mental health issues such as anxiety, depression, and mood disorders. Thus, the harmful effects of nicotine addiction are multi-faceted and far-reaching.
Having described the harmful effects of tobacco, we would be amiss not to mention the beneficial use of tobacco by Indian tribes. Tobacco use in First Nation ceremonies holds significant spiritual and cultural value. It is often used in rituals and offerings, symbolizing respect, gratitude, and communion with the spirits of nature. Tobacco use is sacred in this context, connecting participants with their ancestors and facilitating communication with the spiritual world. This ceremonial use often promotes community cohesion, fostering a sense of unity and shared identity among participants. Moreover, the ceremonial use of tobacco can even have psychological benefits, providing peace and well-being. Therefore, tobacco use in First Nation ceremonies has considerable subjective benefits, integral to their beliefs and traditions.
In general, when using cannabinoid-based therapeutics that contain both THC and CBD consider the ratio between them and weigh the relevant information displayed in the individual THC and CBD Drug Interaction windows accordingly.
If you are interested in the interaction potential of specific pharmaceuticals with both primary cannabinoids and THC/CBD, consider visiting these free drug interaction checkers: Drugs.com or DrugBank Online.
Concerns about Cannabis and Cancer-related Immunotherapies:
Some recent clinical observational studies have suggested that the co-administration of cannabinoid-based therapeutics and immunotherapy or immune checkpoint inhibitors in the treatment of certain types of cancer has been associated with worse overall survival rates (T. Taha et al., 2019; A. Biedny et al., 2020; G. Bar-Sela et al., 2020).
However, other studies have suggested that the co-commitment use of immune checkpoint inhibitors and cannabis-induced no such deleterious effects. More specifically, one trial was conducted on animals resulting in data suggesting that cannabis did not negatively affect the properties of immune checkpoint inhibitors (B. Waissengrin et al., 2023). The same authors compared the previous study results with findings from a cohort of 201 patients with metastatic non-small cell lung cancer who received treatment with monotherapy pembrolizumab as a first-line treatment and adjunct cannabis to treat mainly pain and loss of appetite. Their time to tumor progression was 6.1 versus 5.6 months, and overall survival differed between 54.9 versus 23.6 months in cannabis-naïve patients and cannabis-using patients, respectively. However, while numerically different, the authors write that these differences were not statistically significant, leading them to suggest that “These data provide reassurance regarding the absence of a deleterious effect of cannabis in this clinical setting.”
Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own licensed physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.