Nicotine Dependence and Withdrawal – Cannabis THC : CBD Ratios

Nicotine Dependence and Withdrawal Research Dashboard

18

Primary Studies

9

Related Studies

27

Total Studies

Clinical Studies

5

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

11

Animal studies

0

Laboratory studies

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CannaKeys has 27 studies associated with Nicotine Dependence and Withdrawal.

Here is a small sampling of Nicotine Dependence and Withdrawal studies by title:


Components of the Nicotine Dependence and Withdrawal Research Dashboard

  • Dosing information available for Nicotine Dependence and Withdrawal
  • Chemotype guidance for treating Nicotine Dependence and Withdrawal with cannabis
  • Synopsis of cannabis research for Nicotine Dependence and Withdrawal
  • Individual study details for Nicotine Dependence and Withdrawal

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Overview - Nicotine Dependence and Withdrawal

Description of Nicotine Dependence and Withdrawal

Nicotine in its various forms (e.g. cigarettes, chews, pipe tobacco, vape pens etc.) is made from the tobacco plant. Both are a potentially lethal. Most acute fatalities occur from either inhalation (concentrated contact in the tobacco work place), skin contact (e.g. harvesting tobacco plants), or ingestion (e.g. a child accidentally ingesting the vape cartridge content). The plant contains a number of stimulants which are enhanced and supplemented by the product makers to maximize its effects of stimulatory effects many of which are toxic to life. A fact supported by the fact by its use as an insecticide. It is highly addictive and carcinogenic. Using nicotine containing product delivers mental-emotional realities that include an increased ability to focus, reduced appetite, enhance memory, improve moods (especially when uncomfortable or anxious) and fine motor abilities for example. On the other hand of the spectrum lies its high addiction potential and its causative or contributive nature in the development of chronic debilitating conditions such as heart disease, cancers, strokes to name but a few.

Disease Classification

Condition: Nicotine Dependence
Disease Family: Addiction
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F17

Nicotine Dependence and Withdrawal Symptoms:

Difficulty concentrating, mood swings (anxiety, anger, irritability, depression), craving for more nicotene, cough, hunger, weightgain, sleep disturbances

Also known as:

Tobacco dependence and withdrawal

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.