Longevity – Cannabis THC : CBD Ratios

Longevity Research Dashboard

7

Primary Studies

5

Related Studies

12

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

3

Animal studies

2

Laboratory studies

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CannaKeys has 12 studies associated with Longevity.

Here is a small sampling of Longevity studies by title:


Components of the Longevity Research Dashboard

  • Dosing information available for Longevity
  • Chemotype guidance for treating Longevity with cannabis
  • Synopsis of cannabis research for Longevity
  • Individual study details for Longevity

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Overview - Longevity

Description of Longevity

According to family research on average only about 25% of what induces longevity has a genetic basis making environmental factors the most significant factors that determine lifespan [Source–Hum Genet. 119(3):312-21]. What is empowering about these findings is that many of the environmental factors that contribute to longevity may be subject to conscious intervention. In other words, we can choose them.

There are several methods or processes that have been posited to be able to extend life at the level of the individual cell and for the whole organism. Here we'll focus mostly on the aspects of cognitive decline (e.g., dementia), facilitation of molecular clearance (i.e., optimization of autophagy e.g., in Alzheimer's disease), homeostatic defense activities, re-establishing optimal homeostatic processes, mitigating neurodegeneration and/or neuro-inflammation (incl. neurogenesis), countering excessive oxidative stress, SIRT activation, caloric restrictions, mind-body approaches, and other modulations via the endocannnabinoidome.

Disease Classification

Condition: Longevity
Disease Family:
Organ System: Integumentary System
ICD-10 Chapter: N/A
ICD-10 Code: N/A

Longevity Symptoms:

Slowing, reversing, mitigating or reducing physical signs and symptoms of aging such as wrinkles, “age spots,” greying hair, loss of muscle mass, loss of height, weight gain (associated with metabolic syndrome, insulin resistance, diabetes), loss of visual focus, loss of energy (i.e., at the level of the cell and the whole body), longer recovery times, male/female menopause, epigenetic changes, mutation, telomere shortening, loss of genetic stability and DNA repair capacities, loss of optimal organ/system functions, dysfunctional autophagy, mitochondrial dysfunction, dysfunction of the ECS, increased vulnerability to develop chronic degenerative illness associated with aging such as cancer, cardiovascular diseases, osteoporosis, and obesity. Slowing, reversing, mitigating or reducing mental-emotional signs and symptoms of sub-optimal ageing may include cognitive decline or dysfunction (e.g., on a spectrum between forgetfulness–dementia), social isolation (e.g., loneliness, hopelessness), mood disorders (e.g., depression, anxiety, rapid fluctuations in mood), ruminating (esp. at night), lack of mental-emotional energy and/or focus, loss of social skills and/of functions.

Also known as:

Life Extension, Anti-aging, Long-life, Long-lived, Vitality, Vigor, Virility, Endurance, Old-age, Extended Life Span, Energy, Golden Years, Resilience

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.