Kidney Stones – Cannabis THC : CBD Ratios

Kidney Stones Research Dashboard

6

Primary Studies

0

Related Studies

6

Total Studies

Clinical Studies

4

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 6 studies associated with Kidney Stones.

Here is a small sampling of Kidney Stones studies by title:


Components of the Kidney Stones Research Dashboard

  • Dosing information available for Kidney Stones
  • Chemotype guidance for treating Kidney Stones with cannabis
  • Synopsis of cannabis research for Kidney Stones
  • Individual study details for Kidney Stones

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Overview - Kidney Stones

Description of Kidney Stones

Kidney Stones are an accumulation of hard matter comprised of mostly salts and minerals. The reason for developing kidney stones is believed to require a combination of factors such as dietary (e.g. excess sodium), environmental (e.g. repeated UTI’s, use of chemotherapies) and history to produce the internal environment that is needed for the stones to build. It is posited that stones tend to aggregate when urine is chronically and densely concentrated due to lack of hydration allowing substances such as uric acid, calcium, cysteine, or struvite for example to stick together. Men are affected more often than females. Small stones tend to pass through the urinary tract from the kidney down the long passageways of the ureters to the bladder without causing any symptoms, while larger stones (>0.5cm), especially those with sharp edges can cause severe, sharp pain in the lower back and flanks (sometimes radiating to the abdomen or groins).

Disease Classification

Condition: Kidney Stones
Disease Family:
Organ System: Urinary System
ICD-10 Chapter: Diseases of the genitourinary system
ICD-10 Code: N20

Kidney Stones Symptoms:

Pains (can be severe) tend to come in waves and moves as the stone makes its way further down the urinary tract. Other common symptoms include dysuria (difficulty passing urine), hematuria (bloody urine), restlessness, sweating, dread (of the next wave) nausea, vomiting and when the internal trauma causes infection fever may be present.

Also known as:

Ureteral Stones, Nephrolithiasis, Calculus of the Kidney, Staghorn Calculus, Ureterolithiasis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.