Hidradenitis Suppurativa/ Acne Inversa – Cannabis THC : CBD Ratios

Hidradenitis Suppurativa/ Acne Inversa Research Dashboard

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Related Studies

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Double-blind human trials

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CannaKeys has 2 studies associated with Hidradenitis Suppurativa/ Acne Inversa.

Here is a small sampling of Hidradenitis Suppurativa/ Acne Inversa studies by title:


Components of the Hidradenitis Suppurativa/ Acne Inversa Research Dashboard

  • Dosing information available for Hidradenitis Suppurativa/ Acne Inversa
  • Chemotype guidance for treating Hidradenitis Suppurativa/ Acne Inversa with cannabis
  • Synopsis of cannabis research for Hidradenitis Suppurativa/ Acne Inversa
  • Individual study details for Hidradenitis Suppurativa/ Acne Inversa

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Overview - Hidradenitis Suppurativa/ Acne Inversa

Description of Hidradenitis Suppurativa/ Acne Inversa

Hidradenitis suppurativa is a relatively rare skin condition that often looks like pimples growing inwards which explains the other name the condition is known by acne inversa. The condition is thought to occurs when hair follicles become blocked and inflamed causing irritation, inflammation, and pain. However, the exact causes are subject to speculation and may include hormonal imbalances, metabolic conditions, hereditary factors, or an out of balance immune response for example. Symptoms most commonly affect axillary and anogenital regions.

Disease Classification

Condition: Acne Inversa
Disease Family: Skin Disease
Organ System: Integumentary System
ICD-10 Chapter: Diseases of the Skin and Subcutaneous Tissue
ICD-10 Code: L73.2

Hidradenitis Suppurativa/ Acne Inversa Symptoms:

"Inverted pimples", chronic inflammation (e.g. red, swollen, pain, heat), commonly occurs after puberty, increased pro-inflammatory cytokenes, common secondary bacterial infections,

Also known as:

HS, Hidradenitis, Hydroadenitis, Pollitzer's disease

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.