Hiccups – Cannabis THC : CBD Ratios

Hiccups Research Dashboard

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Double-blind human trials

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CannaKeys has 1 studies associated with Hiccups.

Here is a small sampling of Hiccups studies by title:


Components of the Hiccups Research Dashboard

  • Dosing information available for Hiccups
  • Chemotype guidance for treating Hiccups with cannabis
  • Synopsis of cannabis research for Hiccups
  • Individual study details for Hiccups

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Overview - Hiccups

Description of Hiccups

Hiccups are involuntary spasms of the diaphragm a sheet-like muscle that separates the abdominal and the thoracic cavities. The diaphragm enables us to breathe, laugh, vomit, and cough for example. Hiccups can occur as a single event but more often are repeating until it resolves spontaneously. Intractable hiccups are of a constant nature and can severely affect quality of life (e.g. lack of sleep, exhaustion). There are a number of natural (e.g. carbonated drinks) and disease related causes (e.g. multiple sclerosis) that contribute to normal hiccups. Intractable hiccups have been reported in certain patient populations (e.g. strokes, AIDS, gliomas)

Disease Classification

Condition: Hiccups
Disease Family: Involuntary Muscle Condition
Organ System: Nervous System
ICD-10 Chapter: Symptoms, Signs and Abnormal Clinical and Laboratory Findings
ICD-10 Code: R06.6

Hiccups Symptoms:

Involuntary contraction of the diaphram, self-limiting or chronic

Also known as:

Hiccoughs, Psychogenic hiccough, Epidemic hiccough

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.