Hepatitis – Cannabis THC : CBD Ratios

Hepatitis Research Dashboard

17

Primary Studies

10

Related Studies

27

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

11

Meta-analyses/Reviews

1

Animal studies

5

Laboratory studies

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CannaKeys has 27 studies associated with Hepatitis.

Here is a small sampling of Hepatitis studies by title:


Components of the Hepatitis Research Dashboard

  • Dosing information available for Hepatitis
  • Chemotype guidance for treating Hepatitis with cannabis
  • Synopsis of cannabis research for Hepatitis
  • Individual study details for Hepatitis

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Overview - Hepatitis

Description of Hepatitis

Hepatitis is inflammation of the liver and can be characterized as acute or chronic. Acute hepatitis usually lasts no more than a couple of months. Chronic hepatitis can be a lifelong debilitating disease. Most commonly, the liver becomes inflamed as a result of the hepatic viruses A, B, C, D, or E, which are a major health problem worldwide. Viral hepatitis is contagious, while non-viral forms of hepatitis are not. However, toxins, alcohol, and many pharmacological medications such as acetaminophen and ibuprofen can also produce hepatitis. Hepatitis can also occur after ingesting poisonous mushrooms, or result from an autoimmune disease in which the body's own immune system attacks the liver. Until very recently, no treatment existed within orthodox medicine to cure hepatitis C. Treatment focused on supporting the body through different stages of the illness. Some of the most common pharmaceutical medications used in the management of hepatitis were immune globulin, interferon, and ribavirin, each with a set of potentially severe adverse effects. Sometimes liver transplants could sustain life. However, a new line of drugs just arrived which has achieved a relatively high cure rate (up to 90%) for hepatitis C (at least genotype 1). The cost for a course of a 12-week treatment of Harvoni, Sovaldi, or Olysio in specific combination can easily surpass six figures.

Disease Classification

Condition: Hepatitis
Disease Family: Liver Disease
Organ System: Digestive System
ICD-10 Chapter: Diseases of the Digestive System
ICD-10 Code: K73

Hepatitis Symptoms:

Jaundice, ascites, brown urine, right upper quadrant pain, nausea/vomiting, lack of appetite

Also known as:

Chronic Hepatitis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.